CAS 1094250-13-1

(-)-englerin b

CAS: 1094250-13-1

Oxygen-heterocyclic compound

Formel: C₂₄H₃₂O₄

Reinheit: ≥ 90.0 % (HPLC)

Molekulargewicht: 384.51

Ref: 5G-83850

Englerin B

CAS: 1094250-13-1

Englerin B is a sesquiterpene lactone, which is a natural product isolated from the plant Phyllanthus engleri. It exerts its effects through selective activation of transient receptor potential canonical (TRPC) channels, particularly TRPC4 and TRPC5. This action initiates a cascade of cellular events leading to apoptosis specifically in renal cancer cells.

Englerin B has garnered attention for its potential therapeutic applications in oncology, particularly for its selective cytotoxicity toward renal cell carcinoma (RCC). Its unique mode of action offers a promising avenue for targeted cancer treatment, minimizing effects on non-cancerous cells. Researchers are exploring its potential as part of combinatory therapies, as well as investigating its underlying molecular mechanisms to better understand its specificity and enhance its clinical application. Continued studies are essential to further elucidate its efficacy and safety profile, which may eventually lead to new therapeutic strategies in cancer care.

Formel: C₂₄H₃₂O₄

Reinheit: Min. 95%

Molekulargewicht: 384.51 g/mol

Ref: 3D-UTB25013