CAS 115035-45-5

Des-Arg9-[Leu8]-Bradykinin acetate

CAS: 115035-45-5

Des-Arg9-[Leu8]-Bradykinin acetate is a potent antagonist of the bradykinin receptor 1 (B1R), utilized in renal fibrosis research [1].

Formel: C₄₃H₆₇N₁₁O₁₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 930.06

Ref: TM-T80072

Des-Arg9-[Leu8]-Bradykinin

Kontrolliertes Produkt

CAS: 115035-45-5

Bradykinin is a peptide hormone that can be formed from the breakdown of kininogen. It works by binding to specific receptors found on the surface of cells and activating a G-protein coupled receptor. Bradykinin stimulates the secretion of gastric acid, increases the permeability of capillaries in the lungs, and causes contraction of smooth muscle in many organs. Bradykinin also has an important role in regulating blood pressure and heart rate. Des-Arg9-[Leu8]-Bradykinin (D-BK) is a potent inhibitor of this activity and is used as an antihypertensive agent. D-BK prevents the activation of G-proteins by binding to receptors with high affinity and specificity. When it binds to its receptor, it inhibits cyclic AMP production, which leads to decreased cell activity and vasodilation. This inhibition reduces blood pressure by reducing cardiac output and increasing systemic vascular resistance.

Formel: C₄₁H₆₃N₁₁O₁₀•CH₃COOH•3H₂O

Reinheit: Min. 95%

Molekulargewicht: 984.11 g/mol

Ref: 3D-PBK-4065