CAS 117399-94-7

Endothelin 1

Beschreibung:

Endothelin-1 (ET-1) ist ein potentes vasokonstriktorisches Peptid, das eine entscheidende Rolle in verschiedenen physiologischen und pathologischen Prozessen spielt, insbesondere im kardiovaskulären System. Es handelt sich um ein 21-Aminosäure-Peptid, das hauptsächlich von Endothelzellen produziert wird und an der Regulierung des Blutdrucks, des Gefäßtonus und des Flüssigkeitsgleichgewichts beteiligt ist. ET-1 ist bekannt für seine Fähigkeit, die Kontraktion der glatten Muskulatur zu induzieren und die Zellproliferation zu fördern, was es in Bedingungen wie Bluthochdruck und Herzinsuffizienz bedeutend macht. Das Peptid entfaltet seine Wirkung über spezifische Rezeptoren, hauptsächlich den Endothelin-Rezeptor Typ A (ETA) und Typ B (ETB), die im gesamten Körper verteilt sind. Neben seinen kardiovaskulären Effekten ist Endothelin-1 auch an verschiedenen anderen biologischen Prozessen beteiligt, einschließlich Entzündung, Zellwachstum und Neurobiologie. Aufgrund seiner starken Wirkungen ist ET-1 ein Ziel für therapeutische Interventionen bei Krankheiten, die durch übermäßige Vasokonstriktion und Gewebsremodellierung gekennzeichnet sind. Seine CAS-Nummer, 117399-94-7, wird zur Identifizierung in chemischen Datenbanken und regulatorischen Kontexten verwendet.

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅

InChl: InChI=1/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)

SMILES: CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)CC)N=C(C(CC(=O)O)N=C(C(CC(C)C)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(CO)C(=NC2CSSCC(C(=NC(C(C)C)C(=NC(Cc3ccc(cc3)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCCCN)N=C(C(CC(=O)O)N=C(C(CCSC)N=C(C(CC(C)C)N=C(C(CO)N=C(C(CO)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O

Synonyme:

• Endothelin 1 human, porcine
• H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11)
• Endothelin 1, Human and Porcine
• Endothelin-1,Human
• Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt

Endothelin-1 (human, bovine, dog, mouse, porcine, rat)

CAS: 117399-94-7

Endothelin-1 (ET-1) is a potent vasoconstrictive 21-amino acid peptide produced by endothelia cells. It acts on endothelia cells and on the underlying smooth muscle cells as a modulator of vascular tone. ET-1 shows selectivity for the ET-A receptor.

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Reinheit: 95.0%

Farbe und Form: White

Molekulargewicht: 2491.94

Ref: 01-4048904

Endothelin-1 (human, bovine, dog, mouse, porcine, rat)

CAS: 117399-94-7

Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis.

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Reinheit: 91.90%

Farbe und Form: White

Molekulargewicht: 2491.94

Ref: 01-4040254

Endothelin-1 Acetate

CAS: 117399-94-7

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Reinheit: 95%~99%

Farbe und Form: White to Off-white Powder

Molekulargewicht: 2491.9

Ref: BP-BPPG025

Endothelin 1 (swine, human)

CAS: 117399-94-7

Endothelin 1, a strong vasoconstrictor, targets ETA/ETB receptors, with a synthetic human/swine peptide sequence.

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Farbe und Form: White Powder

Molekulargewicht: 2491.9

Ref: TM-T19309

Endothelin-1

CAS: 117399-94-7

Endothelin-1

Farbe und Form: White Powder

Molekulargewicht: 2,491.90g/mol

Ref: 54-BIBA1014

Endothelin-1 (Human)

CAS: 117399-94-7

Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.1mg vial.

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Reinheit: Min. 95%

Molekulargewicht: 2,491.9 g/mol

Ref: 3D-PED-4198-S

Endothelin-1 (Human)

CAS: 117399-94-7

Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle.
This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.5mg vial.

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Reinheit: Min. 95%

Molekulargewicht: 2,491.9 g/mol

Ref: 3D-PED-4198-V

Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate

CAS: 117399-94-7

Endothelin-1 (ET-1) is a peptide that is produced by the endothelium. ET-1 is involved in numerous biological processes, including vasoconstriction, inflammation, and cell proliferation. Endothelin-1 (human ET-1) acetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-(Glu)-Cys-(Val)-Tyr-(Phe)-Cys-(His)-Leu -Asp(-Ile)-Ile(-Trp)) acetate salt is a recombinant protein that has been shown to significantly upregulate the production of endothelin in primary pulmonary hypertension. It also plays an important role in bowel disease, where it may be involved in the development of chronic inflammatory bowel disease.

Formel: C₁₀₉H₁₅₉N₂₅O₃₂S₅•(C₂H₄O₂)x

Reinheit: Min. 95%

Molekulargewicht: 2,491.91 g/mol

Ref: 3D-FE109997