CAS 121695-87-2

Sarafotoxin S6C

Beschreibung:

Sarafotoxin S6C ist ein Peptidtoxin, das aus dem Gift bestimmter Schlangenarten, insbesondere aus der Familie Viperidae, gewonnen wird. Es ist bekannt für seine potente biologische Aktivität, hauptsächlich als Neurotoxin, das das Herz-Kreislauf-System beeinflusst. Sarafotoxin S6C zeigt eine hohe Affinität zu spezifischen Rezeptoren, was zu einer Vasokonstriktion und einem Anstieg des Blutdrucks führt. Seine Struktur umfasst typischerweise eine Reihe von Aminosäuren, die in einer spezifischen Sequenz angeordnet sind, was zu seiner Stabilität und Aktivität beiträgt. Das Toxin wird häufig auf seine potenziellen Implikationen in der Pharmakologie und Toxikologie untersucht, da es Einblicke in Rezeptorinteraktionen und Signalwege geben kann. Darüber hinaus ist Sarafotoxin S6C aufgrund seiner biologischen Wirkungen von Interesse in der Forschung zu Bluthochdruck und anderen Herz-Kreislauf-Erkrankungen. Sicherheitsvorkehrungen sind beim Umgang mit dieser Substanz unerlässlich, da sie erhebliche Gesundheitsrisiken darstellen kann. Insgesamt dient Sarafotoxin S6C als wertvolles Modell zum Verständnis der Mechanismen von Peptidtoxinen und ihrer potenziellen therapeutischen Anwendungen.

Formel: C₁₀₃H₁₄₇N₂₇O₃₇S₅

InChl: InChI=1/C103H147N27O37S5/c1-10-46(6)80(100(163)123-67(103(166)167)30-50-37-109-54-19-15-14-18-52(50)54)128-99(162)79(45(4)5)127-95(158)66(36-78(144)145)120-85(148)55(20-23-71(105)133)112-90(153)61(31-51-38-108-43-110-51)117-97(160)69-40-170-169-39-53(104)83(146)129-81(47(7)131)102(165)126-70-42-172-171-41-68(96(159)115-59(28-44(2)3)88(151)118-62(32-72(106)134)91(154)116-60(89(152)125-69)29-49-16-12-11-13-17-49)124-86(149)57(22-25-75(138)139)111-84(147)56(21-24-74(136)137)113-94(157)65(35-77(142)143)122-101(164)82(48(8)132)130-87(150)58(26-27-168-9)114-93(156)64(34-76(140)141)121-92(155)63(33-73(107)135)119-98(70)161/h11-19,37-38,43-48,53,55-70,79-82,109,131-132H,10,20-36,39-42,104H2,1-9H3,(H2,105,133)(H2,106,134)(H2,107,135)(H,108,110)(H,111,147)(H,112,153)(H,113,157)(H,114,156)(H,115,159)(H,116,154)(H,117,160)(H,118,151)(H,119,161)(H,120,148)(H,121,155)(H,122,164)(H,123,163)(H,124,149)(H,125,152)(H,126,165)(H,127,158)(H,128,162)(H,129,146)(H,130,150)(H,136,137)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167)

SMILES: CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(CCC(=N)O)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(C(C)O)C(=NC2CSSCC(C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCC(=O)O)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(CCSC)N=C(C(CC(=O)O)N=C(C(CC(=N)O)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O

Synonyme:

• Srtx-C
• Sarafotoxin S6C (Atractaspis Engaddensis)
• Sarafotoxin S6C, Atractaspsis Engaddensis
• Sarafotoxin 6C
• Sarafotoxin C
• Sarafotoxin C (Atractaspis Engaddensis)
• Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp

Sarafotoxin C

CAS: 121695-87-2

Highly selective ET-B receptor agonist.

Formel: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Reinheit: > 95%

Farbe und Form: White Powder

Molekulargewicht: 2515.79

Ref: 01-4031255

Sarafotoxin S6c

CAS: 121695-87-2

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Formel: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 2516

Ref: TM-TP2120

Sarafotoxin S6c

CAS: 121695-87-2

Formel: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Reinheit: ≥ 95.0%

Farbe und Form: White lyophilised powder

Molekulargewicht: 2515.75

Ref: 7W-GK0055

Sarafotoxin S6c

CAS: 121695-87-2

Sarafotoxin S6c, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.
Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction. Compared to the sarafotoxin isopeptide S6b, S6c is less toxic with a 100 to 10,000-fold reduced affinity for the ETA receptor, therefore acts as a selective agonist to the ETB receptor. One study demonstrated that when sarafotoxin 6c was used to activate ETB receptors in rats there was an increase in arterial pressure, known as S6c-induced hypertension.
As the upregulation of Endothelin-1 (ET-1) is related to circulatory-system diseases, the interaction between ET-1 and its receptors is highly important for development of endothelin receptor antagonist treatments. Sarafotoxin S6c can be used as a pharmacological reagent to study these interactions.

Formel: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Reinheit: Min. 95%

Molekulargewicht: 2,515.8 g/mol

Ref: 3D-PSF-4246-S

Sarafotoxin C trifluoroacetate salt

CAS: 121695-87-2

Sarafotoxin C is a peptide from the venom of the spider Phoneutria nigriventer that has been shown to have potent inhibitory properties on endothelin-1. Sarafotoxin C is able to block intracellular Ca2+ levels and signal pathways, leading to decreased levels of endothelin-1 as well as other inflammatory mediators. Sarafotoxin C has also been shown to have an anti-inflammatory effect in bowel disease, which may be due to its ability to inhibit the production of cytokines and prostaglandins. The biological properties of sarafotoxin C are related to its inhibition of polymerase chain reaction (PCR) amplification of DNA. This inhibition is due to the binding of sarafotoxin C with endothelin receptors on DNA, which prevents DNA polymerase from attaching. Endothelin-a receptor activity can also be inhibited by sarafotoxin C through enzymatic inactivation. Sarafot

Formel: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Reinheit: Min. 95%

Molekulargewicht: 2,515.76 g/mol

Ref: 3D-FS110267