CAS 122018-58-0

PLP (139-151)

Beschreibung:

PLP, oder Pyridoxalphosphat, ist die aktive Form von Vitamin B6 und spielt eine entscheidende Rolle als Coenzym in verschiedenen biochemischen Reaktionen, insbesondere im Aminosäurestoffwechsel. Es zeichnet sich durch seine Fähigkeit aus, an Transaminierungs-, Decarboxylierungs- und Racemierungsreaktionen teilzunehmen, wodurch die Umwandlung von Aminosäuren und die Synthese von Neurotransmittern erleichtert wird. Die Substanz ist ein gelbes kristallines Pulver, das in Wasser löslich ist und ein pH-abhängiges Stabilitätsprofil aufweist, das unter neutralen bis leicht alkalischen Bedingungen stabiler ist. PLP ist essentiell für die ordnungsgemäße Funktion von Enzymen, die am Stoffwechsel von Kohlenhydraten, Lipiden und Aminosäuren beteiligt sind, was es für zahlreiche physiologische Prozesse lebenswichtig macht. Ein Mangel an PLP kann zu verschiedenen Gesundheitsproblemen führen, einschließlich Anämie und neurologischen Störungen. Seine CAS-Nummer, 122018-58-0, identifiziert es eindeutig in chemischen Datenbanken und unterstützt die Forschung und regulatorischen Kontexte. Insgesamt ist PLP eine bedeutende biochemische Verbindung mit vielfältigen Rollen in der menschlichen Gesundheit und im Stoffwechsel.

Formel: C₇₂H₁₀₄N₂₀O₁₇

Synonyme:

• Proteolipid Protein
• Myelin Proteolipid Protein Fragment (139-151)
• (Ser140)-Myelin Proteolipid Protein (139-151), Depalmitoylated, Human, Bovine, Dog, Mouse, Rat
• [Ser140]-Myelin Proteolipid Protein (139-151) (Human, Bovine, Dog, Mouse, Rat)
• H2N-Hslgkwlghpdkf-Oh

(Ser¹⁴⁰)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat)

CAS: 122018-58-0

This fragment of myelin proteolipid protein is an encephalitogenic determinant, able to bind to diverse sets of T cell receptors.

Formel: C₇₂H₁₀₄N₂₀O₁₇

Reinheit: 97.0%

Farbe und Form: White

Molekulargewicht: 1521.74

Ref: 01-4030575

[SER140]-PLP(139-151)

CAS: 122018-58-0

[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin.

Formel: C₇₂H₁₀₄N₂₀O₁₇

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 1521.72

Ref: TM-TP1312

PLP (139-151)

CAS: 122018-58-0

PLP (139-151) is derived from Proteolipid Protein (PLP), an epitope of immunodominant encephalitogenic PLP and is involved in promoting encephalomyelitis.

Formel: C₇₂H₁₀₄N₂₀O₁₇

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 1,520.8 g/mol

Ref: 3D-CRB1000865

PLP (139-151)

CAS: 122018-58-0

PLP (139-151) peptide is a fragment of myelin proteolipid protein (PLP or lipophilin), from amino acid residue 139 to 151 (HCLGKWLGHPDKF – CAS 131334-43-5 ). Myelin proteolipid protein is the major myelin protein from the central nervous system. PLP (139-151) peptide is commonly used to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J mice. The PLP (139-151) peptide C140S is mutant of the wild-type version where the cystein is replaced by a serine to make the peptide more stable without impacting its antigenic activity.

Formel: C₇₂H₁₀₄N₂₀O₁₇

Molekulargewicht: 1,521.7 g/mol

Ref: 3D-PP50157

Myelin PLP (139-151)

CAS: 122018-58-0

Myelin PLP (139-151) is a basic protein that belongs to the family of oligodendrocyte-myelin glycoproteins. It has been shown to activate toll-like receptor, which is a pattern recognition receptor that recognizes invading pathogens and triggers an immune response. Myelin PLP (139-151) may play a role in the development of autoimmune diseases, as it has been found to be a target for autoantibodies. It has also been shown to have antioxidative properties, which may help prevent free radical damage in the brain and other tissues. The monoclonal antibody against this protein can be used for immunohistological analysis.

Formel: C₇₂H₁₀₄N₂₀O₁₇

Reinheit: Min. 95%

Molekulargewicht: 1,521.72 g/mol

Ref: 3D-PLP-3812-PI

Myelin PLP (139-151) acetate

CAS: 122018-58-0

Myelin PLP (139-151) acetate salt is a cyclic peptide that is derived from the sequence of human myelin basic protein and contains the sequence PLP (139-151). This peptide has shown to have antioxidative properties. It has been shown to have an inhibitory effect on the production of proinflammatory cytokines in experimental autoimmune encephalomyelitis (EAE), which is a model for multiple sclerosis. The peptide has also been shown to block signal pathways, such as toll-like receptor 4, and decrease Ca2+ overload. Clinical relevance remains unclear.

Formel: C₇₂H₁₀₄N₂₀O₁₇•(C₂H₄O₂)x

Reinheit: Min. 95%

Molekulargewicht: 1,521.76 g/mol

Ref: 3D-PLP-3602-PI

(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt

CAS: 122018-58-0

Ser140-Myelin Proteolipid Protein (139-151) is an experimental autoimmune encephalomyelitis (EAE) adjuvant that is used to induce EAE in animals. The peptide has been shown to be mononuclear, encephalitogenic, and capable of inducing cell proliferation. Ser140-Myelin Proteolipid Protein (139-151) has been shown to induce EAE when injected into the animals with a pre-existing immunity to myelin basic protein. Ser140-Myelin Proteolipid Protein (139-151) is also mannosylated and can be used as an experimental adjuvant for immunization.

Formel: C₇₂H₁₀₄N₂₀O₁₇

Reinheit: Min. 95%

Molekulargewicht: 1,521.72 g/mol

Ref: 3D-FS108682