CAS 1220973-37-4

AKP-11

CAS: 1220973-37-4

AKP-11 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing human S1P1. It reduces S1P1 surface expression and enhances Akt and ERK phosphorylation in CHO cells with S1P1-HA at a 100 nM concentration. At doses of 1.3 and 3 mg/kg, AKP-11 lowers IFN-γ and IL-17 protein levels in the spinal cord and mitigates disease severity in a rat experimental autoimmune encephalomyelitis (EAE) model. Additionally, it decreases peripheral total lymphocyte and specific T cell subsets (CD4+, CD8+, and CD26L+ T cells) counts in both EAE rats and healthy controls at a 1.3 mg/kg dosage.

Formel: C₂₂H₂₂ClN₃O₅

Farbe und Form: Solid

Molekulargewicht: 443.88

Ref: TM-T85077

2-Amino-2-(5-(5-(3-chloro-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

CAS: 1220973-37-4

2-Amino-2-(5-(5-(3-chloro-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol is a potent and selective inhibitor of protein interactions. 2DAPB binds to the active site of the enzyme adenylyl cyclase (AC), inhibiting the generation of cAMP. This inhibition leads to decreased signaling through Gs proteins and increased signaling through Gi proteins. 2DAPB has been shown to inhibit the binding of acetylcholine to the muscarinic receptor M1 in vitro with an IC50 value of 0.6 μM. 2DAPB has also been shown to be more potent than atropine in inhibiting binding of acetylcholine to muscarinic receptors, but less potent than hexamethonium in inhibiting binding of acetyl

Formel: C₂₂H₂₂ClN₃O₅

Reinheit: Min. 95%

Molekulargewicht: 443.9 g/mol

Ref: 3D-VYB97337