CymitQuimica logo

CAS 1241675-76-2

:

1-Butanol, 2-[[9-(1-methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-, hydrochlorid (1:2), (2R)-

Beschreibung:
Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3αβ(IC50= 4.1μM). Also shown to inhibit amyloid-βproduction in N2A-APP695cells.
Formel:C23H28ClN7O
InChl:InChI=1S/C23H27N7O.2ClH/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);2*1H/t17-;;/m1../s1
InChI Key:InChIKey=BQPRBNGSDBTKAK-ZEECNFPPSA-N
SMILES:N(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](CC)CO)=N1)C3=CC(=CC=C3)C4=CC=CC=N4.Cl
Synonyme:
  • 1-Butanol, 2-[[9-(1-methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-, hydrochloride (1:2), (2R)-
  • (R)-DRF 053 dihydrochloride
  • DRF053
  • DRF 053
Sortieren nach
Reinheit (%)
0
100
|
0
|
50
|
90
|
95
|
100
4 Produkte gefunden.