CAS 1251839-15-2

SPA0355

CAS: 1251839-15-2

SPA0355 is a synthetic analog of CXCL12 that has been shown to inhibit the activity of NF-κB target genes in hematopoietic cells. It also inhibits the production of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. SPA0355 has been shown to have immunomodulatory effects in experimental models of inflammatory diseases. The mechanism by which SPA0355 inhibits NF-κB target genes is unknown, but it may be due to its ability to bind with fatty acids that are involved in the regulation of cell signaling pathways.

Formel: C₂₂H₂₁N₃O₂S

Reinheit: Min. 95%

Molekulargewicht: 391.5 g/mol

Ref: 3D-BAC83915

SPA0355

CAS: 1251839-15-2

SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.

Formel: C₂₂H₂₁N₃O₂S

Farbe und Form: Solid

Molekulargewicht: 391.486

Ref: TM-T204711