CAS 1256584-81-2

Alectinib Impurity 29

CAS: 1256584-81-2

Formel: C₂₈H₂₉N₃O₃

Molekulargewicht: 455.56

Ref: 4Z-A-239041

8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

Kontrolliertes Produkt

CAS: 1256584-81-2

Applications 8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile is an intermediate used in the synthesis of Alectinib M4 metabolite (A521150), which is the major active metabolite of Alectinib. Alectinib is an anaplastic lymphoma kinase (ALK) inhibitor and is used to treat non-​small-​cell lung cancer by blocking the activity of anaplastic lymphoma kinase (ALK).
References Heinig, K., et al.: Bioanalysis, 8, 1465-79 (2016); Morcos, P.N., et al.: Xenobiotica, 47, 217-29 (2017);

Formel: C₂₈H₂₉N₃O₃

Farbe und Form: Neat

Molekulargewicht: 455.548

Ref: TR-D485310