CAS 129203-60-7

Iberiotoxin von Buthus tamulus

Beschreibung:

Iberiotoxin, abgeleitet vom Gift des indischen roten Skorpions (Buthus tamulus), ist ein potentes Neurotoxin, das für seine selektive Hemmung bestimmter Kaliumkanäle bekannt ist, insbesondere der spannungsabhängigen Kaliumkanäle (Kv) in erregbaren Geweben. Diese Eigenschaft macht es zu einem wertvollen Werkzeug in der Neuropharmakologie zur Untersuchung der Funktion von Ionenkanälen und der physiologischen Rollen von Kaliumkanälen in verschiedenen zellulären Prozessen. Iberiotoxin zeigt eine hohe Affinität zum Kv1.3-Kanal, der an Immunantworten und neuronaler Erregbarkeit beteiligt ist. Die Struktur des Toxins ist durch eine Polypeptidkette gekennzeichnet, die sich in eine spezifische dreidimensionale Konformation faltet, die es ihr ermöglicht, effektiv mit ihren Zielkanälen zu interagieren. Ihr Wirkmechanismus umfasst die Bindung an den Kanal und die Verhinderung des Kaliumionenflusses, was zu einer verlängerten Depolarisation von Neuronen und Muskelzellen führen kann. Aufgrund ihrer starken Wirkungen ist Iberiotoxin auch von Interesse in der Forschung zu Schmerz, Entzündung und potenziellen therapeutischen Anwendungen, obwohl ihre Verwendung hauptsächlich auf Laborumgebungen aufgrund ihrer Toxizität beschränkt ist.

Formel: C₁₇₉H₂₇₄N₅₀O₅₅S₇

InChl: InChI=1/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(167(273)205-109(56-64-285-12)145(251)194-76-132(238)197-101(39-21-26-57-180)147(253)200-105(43-25-30-61-184)151(257)220-123-81-286-288-83-125(221-152(258)106(203-166(123)272)45-32-63-191-179(188)189)169(275)210-113(68-95-46-48-97(234)49-47-95)156(262)206-110(177(283)284)50-53-129(185)235)82-287-291-86-128(168(274)202-104(42-24-29-60-183)150(256)212-116(70-135(242)243)159(265)207-111)224-175(281)142(91(9)10)228-164(270)121(79-231)216-157(263)115(69-96-74-192-99-38-20-19-37-98(96)99)211-170(276)126-84-289-290-85-127(171(277)217-122(80-232)165(271)227-141(90(7)8)174(280)218-120(78-230)163(269)201-103(41-23-28-59-182)149(255)204-108(154(260)222-126)52-55-134(240)241)223-160(266)118(72-137(246)247)214-173(279)140(89(5)6)226-162(268)119(73-138(248)249)215-176(282)143(92(11)233)229-161(267)114(67-94-35-17-14-18-36-94)209-153(259)107-51-54-130(236)196-107/h13-20,33-38,46-49,74,87-92,100-128,139-143,192,230-234H,21-32,39-45,50-73,75-86,180-184H2,1-12H3,(H2,185,235)(H,193,250)(H,194,251)(H,195,252)(H,196,236)(H,197,238)(H,198,237)(H,199,264)(H,200,253)(H,201,269)(H,202,274)(H,203,272)(H,204,255)(H,205,273)(H,206,262)(H,207,265)(H,208,261)(H,209,259)(H,210,275)(H,211,276)(H,212,256)(H,213,278)(H,214,279)(H,215,282)(H,216,263)(H,217,277)(H,218,280)(H,219,254)(H,220,257)(H,221,258)(H,222,260)(H,223,266)(H,224,281)(H,225,239)(H,226,268)(H,227,271)(H,228,270)(H,229,267)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,283,284)(H4,186,187,190)(H4,188,189,191)

SMILES: CC(C)CC1C(=NC(Cc2ccccc2)C(=NCC(=NC(C(C)C)C(=NC(CC(=O)O)C(=NC(CCCNC(=N)N)C(=NCC(=NC(CCCCN)C(=NC(CSSCC(C(=NC(CCCCN)C(=NC(CC(=O)O)C(=N1)O)O)O)N=C(C(C(C)C)N=C(C(CO)N=C(C(Cc1c[nH]c2ccccc12)N=C(C1CSSCC(C(=NC(CO)C(=NC(C(C)C)C(=NC(CO)C(=NC(CCCCN)C(=NC(CCC(=O)O)C(=N1)O)O)O)O)O)O)N=C(C(CC(=O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(Cc1ccccc1)N=C(C1CCC(=N1)O)O)O)O)O)O)O)O)O)O)O)C(=NC(CCSC)C(=NCC(=NC(CCCCN)C(=NC(CCCCN)C(=NC1CSSCC(C(=NC(Cc2ccc(cc2)O)C(=NC(CCC(=N)O)C(=O)O)O)O)N=C(C(CCCNC(=N)N)N=C1O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

Synonyme:

• Iberiotoxin, Buthus tamulus
• Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bonds between Cys7 and Cys28/Cys13 and Cys33/ Cys17 and Cys35)
• Iberiotoxin

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin (IbTx), from the venom of the scorpion Buthus tamulus, shows 68% sequence homology with charybdotoxin, another scorpion-derived peptidyl toxin. Although these two toxins both inhibit the high conductance Ca²⁺ activated K⁺ channel, they appear to bind at different sites on the channel and modulate channel activity by different mechanisms. Thus, iberiotoxin can be used to selectively study the function of the high conductance Ca²⁺ activated K⁺ channel.

Formel: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Reinheit: > 95%

Farbe und Form: Whitish Powder

Molekulargewicht: 4230.91

Ref: 01-4030755

2-(2-{[10-(2-{2-[2-(2-{[7,34-bis(4-aminobutyl)-25-benzyl-13-(3-carbamimidamidopropyl)-16,31-bis(carboxymethyl)-28-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-19-(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriaco

CAS: 129203-60-7

Formel: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Reinheit: ≥95%

Molekulargewicht: 4230.8479

Ref: IN-DA000YY4

Iberiotoxin

CAS: 129203-60-7

Selective blocker of the big conductance Ca2+-activated K+ channel.

Formel: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 4230

Ref: TM-TP2014

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iberiotoxin on various ion channels and receptors.

Formel: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Reinheit: Min. 95%

Molekulargewicht: 4,230.8 g/mol

Ref: 3D-PIB-3813-PI

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin is a neurotoxin that is synthesized by the bacterium Clostridium botulinum. It inhibits the activity of a number of enzymes, including protein kinase C and cyclase, but has no effect on phosphatases. Iberiotoxin has been shown to be effective against models systems of bowel disease, such as colonic inflammation and ulceration. Iberiotoxin binds to specific neuronal receptors in the central nervous system, leading to inhibition of intracellular calcium levels, which may play an important role in the mechanisms of action for this toxin.

Formel: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Reinheit: Min. 95%

Molekulargewicht: 4,230.86 g/mol

Ref: 3D-FI110468

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iveriotoxin on various ion channels and receptors. This product is available as a 0.1mg vial.

Formel: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Reinheit: Min. 95%

Molekulargewicht: 4,230.8 g/mol

Ref: 3D-PIB-4235-S