CAS 1330180-22-7

Nimesulide-d5

CAS: 1330180-22-7

Formel: C₁₃H₇D₅N₂O₅S

Farbe und Form: Pale Yellow Solid

Molekulargewicht: 313.34

Ref: 4Z-N-083

Nimesulide D5

CAS: 1330180-22-7

Nimesulide D5 is a deuterium labeled Nimesulide. Nimesulide is a selective inhibitor OF COX-2(IC50s of 70 nM-70 μM)

Formel: C₁₃H₁₂N₂O₅S

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 313.34

Ref: TM-T12227

Nimesulide-d5

Kontrolliertes Produkt

CAS: 1330180-22-7

Applications Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)

Formel: C₁₃H₇D₅N₂O₅S

Farbe und Form: Neat

Molekulargewicht: 313.34

Ref: TR-N477502

Nimesulide-d5

CAS: 1330180-22-7

Nimesulide-d5 is a 5-fluorinated derivative of nimesulide, which is a nonsteroidal anti-inflammatory drug. Nimesulide-d5 has been shown to have an increased terminal half-life in humans and healthy Chinese subjects, as well as reduced glucuronide conjugate formation. This drug also has an enhanced particle size and improved spectral properties for use in chromatographic applications. Nimesulide-d5 is clinically relevant for the treatment of cancer and acetaminophen induced hepatotoxicity. It is metabolized into its active form by cytochrome P450 enzymes, leading to the inhibition of protein synthesis in cancer cells and the prevention of liver toxicity due to acetaminophen overdose.

Formel: C₁₃H₇D₅N₂O₅S

Reinheit: Min. 95%

Molekulargewicht: 313.34 g/mol

Ref: 3D-FDC18022