CAS 138-14-7

Deferoxaminmesilat

Beschreibung:

Deferoxaminmesilat ist ein Chelatbildner, der hauptsächlich zur Behandlung von Eisenüberladungserkrankungen eingesetzt wird, wie sie bei wiederholten Bluttransfusionen bei Patienten mit Erkrankungen wie Thalassämie oder Sichelzellenanämie auftreten. Es handelt sich um eine wasserlösliche Verbindung, die stabile Komplexe mit ferrischen Ionen bildet und deren Ausscheidung aus dem Körper erleichtert. Die Substanz stammt von dem Bakterium *Streptomyces pilosus* und zeichnet sich durch ihre Fähigkeit aus, selektiv Eisen zu binden, wodurch ihre Toxizität verringert und Organschäden verhindert werden. Deferoxaminmesilat wird typischerweise subkutan oder intravenös verabreicht, und seine Pharmakokinetik umfasst eine schnelle Verteilung und renale Ausscheidung. Die Verbindung ist bekannt für ihr relativ niedriges Toxizitätsprofil, obwohl mögliche Nebenwirkungen allergische Reaktionen, gastrointestinale Störungen und Auswirkungen auf das Sehvermögen bei längerer Anwendung umfassen können. Ihre Wirksamkeit bei der Behandlung von Eisenüberladung hat sie zu einem wichtigen therapeutischen Mittel in der Hämatologie und Onkologie gemacht.

Formel: C₂₅H₄₈N₆O₈·CH₄O₃S

InChl: InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)

InChI Key: InChIKey=IDDIJAWJANBQLJ-UHFFFAOYSA-N

SMILES: S(C)(=O)(=O)O.C(CCC(NCCCCCN(C(C)=O)O)=O)(N(CCCCCNC(CCC(N(CCCCCN)O)=O)=O)O)=O

Synonyme:

• Ba 33112
• Butanediamide, N⁴-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N¹-(5-aminopentyl)-N¹-hydroxy-, methanesulfonate (1:1)
• Butanediamide, N′-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt)
• DFX mesylate
• Deferoxamine B mesylate
• Deferoxamine Mesilate
• Deferoxamine methanesulfonate
• Deferrioxamine B methanesulfonate
• Deferrioxamine methanesulfonate
• Desferal
• Desferal mesylate
• Desferrioxamine B mesylate
• Desferrioxamine B methanesulfonate
• Desferrioxamine mesilate
• Desferrioxamine mesylate
• Desferrioxamine methanesulfonate
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:1)
• N'-{5-[acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxybutanediamide methanesulfonate (1:2)
• NSC 644468
• Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, methanesulfonate
• Propionohydroxamic acid, N-[5-[3-[(5-aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]-, monomethanesulfonate (salt)

Deferoxamine Mesylate

CAS: 138-14-7, 70-51-9

Formel: C₂₅H₄₈N₆O₈·CH₄O₃S

Reinheit: >97.0%(T)(HPLC)

Farbe und Form: White to Light yellow powder to crystal

Molekulargewicht: 656.79

Ref: 3B-D4245

Desferrioxamine mesilate

CAS: 138-14-7

Desferrioxamine mesilate

Formel: C₂₇H₅₆N₆O₁₄S₂

Farbe und Form: Off-White

Molekulargewicht: 752.8953

Ref: 47-987

DEFEROXAMINE FOR PEAK IDENTIFICATION CRS

CAS: 138-14-7

DEFEROXAMINE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0001937

DEFEROXAMINE MESILATE CRS

CAS: 138-14-7

DEFEROXAMINE MESILATE CRS

Formel: C₂₇H₅₆N₆O₁₄S₂

Molekulargewicht: 752.8953

Ref: 41-D0160000

Deferoxamine Mesylate

CAS: 138-14-7

Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugs

Formel: C₂₅H₄₈N₆O₈·CH₄O₃S

Farbe und Form: White Powder

Molekulargewicht: 656.34148

Ref: 45-1166003

Deferoxamine mesylate

CAS: 138-14-7

Formel: C₂₆H₅₂N₆O₁₁S

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 656.7897

Ref: IN-DA007ZDX

Deferoxamine Mesylate

CAS: 138-14-7

Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.

Formel: C₂₆H₅₂N₆O₁₁S

Reinheit: 94.68% - 99.8%

Farbe und Form: Solid

Molekulargewicht: 656.79

Ref: TM-T1637

Deferoxamine Mesylate

CAS: 138-14-7

Deferoxamine Mesylate

Reinheit: ≥90%

Molekulargewicht: 656.79g/mol

Ref: 54-BUP17037

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine mesylate

Formel: C₂₅H₄₈N₆O₈·CH₃SO₃H

Reinheit: By hplc: 99.0% by area (Typical Value in Batch COA)

Farbe und Form: white solid

Molekulargewicht: 656.79g/mol

Ref: 54-BIB6311

Desferrioxamine B mesylate

CAS: 138-14-7

Formel: C₂₅H₄₈N₆O₈·CH₄O₃S

Reinheit: ≥ 98.0%

Farbe und Form: White to almost white powder

Molekulargewicht: 656.79

Ref: 7W-GP5073

Deferoxamine Mesilate RS

CAS: 138-14-7

Farbe und Form: White Solid Powder

Ref: 2K-1086000021

Deferoxamine Mesylate

Kontrolliertes Produkt

CAS: 138-14-7

Applications An iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients
References Inati, A. et al.: Am. J. Hematol., 85, 782 (2010); Selim, M.: Translat. Stroke Res., 1, 35 (2010); Cappellini, M.D. et al.: Hemoblobin, 33, 258 (2009);

Formel: C₂₅H₄₈N₆O₈·CH₄O₃S

Farbe und Form: Off-White

Molekulargewicht: 656.79

Ref: TR-D228980

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine is a very well known drug for the treatment of iron excess occurring in patients with thalassemia who are receiving regular transfusions. Excessive iron intake from diet may also cause accumulation of the metal ions which result in several symptoms such as metabolic acidosis and hypovolemic shock. The mechanism of action of Deferoxamine is based on its ability to chelate iron and other metal ions (i.e. aluminum) permitting their rapid urinary elimination. Recently, another potential therapeutic uses of Deferoxamine for treating diabetic neuropathy was suggested since it was observed that the drug could activate the production of pro-angiogenic, neuroprotective and anti inflammatory factors. Read the full story here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178011

Formel: C₂₆H₅₂N₆O₁₁S

Reinheit: Min. 98.0 Area-%

Molekulargewicht: 656.79 g/mol

Ref: 3D-D-0675

Deferoxamine mesylate

CAS: 138-14-7

Deferoxamine mesylate is an iron chelator that is used in the treatment of iron overload and to treat patients with chronic renal failure. Deferoxamine mesylate has been shown to inhibit angiogenesis by inhibiting the basic protein required for this process. It is also known to have a protective effect on myocardial cells, preventing cell death due to lack of oxygen (reactive oxygen species). Deferoxamine mesylate also inhibits neuronal death in a model system.
Deferoxamine mesylate binds to DNA and inhibits RNA synthesis, which has led to its use as a fluorescence probe for the detection of DNA binding activity. The drug has also been shown to act as a metal chelate, binding with metals such as iron, copper, and zinc.

Formel: C₂₆H₅₂N₆O₁₁S

Reinheit: Min. 95 Area-%

Farbe und Form: Powder

Molekulargewicht: 656.79 g/mol

Ref: 3D-FD20885