CAS 13870-90-1

Coenzym B12

Beschreibung:

Coenzym B12, auch bekannt als Methylcobalamin, ist ein lebenswichtiger Cofaktor in verschiedenen biochemischen Prozessen, insbesondere im Metabolismus von Homocystein und der Synthese von Methionin. Es ist ein wasserlösliches Vitamin, das zur B-Vitamin-Gruppe gehört, speziell zur Gruppe B12, die mehrere Formen von Cobalamin umfasst. Coenzym B12 ist durch seine komplexe Struktur gekennzeichnet, die ein Cobalt-Ion im Kern enthält, das an einen Corrinring koordiniert ist, und zeichnet sich durch das Vorhandensein einer Methylgruppe aus. Diese Verbindung spielt eine entscheidende Rolle im Zellstoffwechsel, insbesondere im zentralen Nervensystem und bei der Bildung von roten Blutkörperchen. Ein Mangel an Coenzym B12 kann zu erheblichen Gesundheitsproblemen führen, einschließlich Anämie und neurologischen Störungen. Es wird hauptsächlich über die Nahrung aufgenommen, insbesondere über tierische Produkte, und ist entscheidend für die Aufrechterhaltung einer ordnungsgemäßen neurologischen Funktion und der DNA-Synthese. Darüber hinaus wird Coenzym B12 häufig in klinischen Einrichtungen verwendet, um Mängel und verwandte Gesundheitszustände zu behandeln.

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

InChl: InChI=1/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2

InChI Key: InChIKey=OAJLVMGLJZXSGX-RQKYJTTQSA-L

SMILES: [CH2-]([Co+3]1234[N]=5[C@@]6(C)[C@@]7([N-]1C([C@@](C)([C@H]7CC(N)=O)CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@H]8C(O)([C@@H](N9C=[N]2C=%10C9=CC(C)=C(C)C%10)O[C@@H]8CO)[H])=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5[C@@H](CCC(N)=O)[C@@]6(CC(N)=O)C)[C@](CC(N)=O)(C)[C@@H]%12CCC(N)=O)C(C)(C)[C@@H]%11CCC(N)=O)[H])[C@H]%13O[C@H]([C@H](O)[C@@H]%13O)N%14C=%15C(N=C%14)=C(N)N=CN%15

Synonyme:

• (5'-Deoxy-5'-adenosyl)cobamide coenzyme
• (5,6-Dimethylbenzimidazolyl)Cobamide Coenzyme
• 5'-Deoxy-5'-adenosylcobalamin
• 5'-Deoxyadenosyl vitamin B12
• 5'-Deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide
• 5'-Deoxyadenosylcobalamin
• 5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide
• 5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
• 5′-Deoxyadenosyl vitamin B₁₂
• Actimide
• Adenosyl B12
• Adenosyl B₁₂
• Adenosylcobalamin
• Anabasi
• Betarin
• Calomide
• Cobalamin coenzyme
• Cobalamin, Co-(5'-deoxy-5'-adenosyl)-
• Cobalion
• Cobamamid
• Cobamamida
• Cobamamide
• Cobamide coenzyme, (5'-deoxy-5'-adenosyl)-
• Cobamide coenzyme, (5,6-dimethyl-1H-benzimidazolyl)-
• Cobamide, Co-(5'-deoxy-5'-adenosyl)-α-(5,6-dimethyl-1H-benzimidazolyl)-
• Cobanzyme
• Cobatlamin S
• Cobazymase
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
• Cobinamide, Co-(5'-deoxyadenosine-5') derivative hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³)
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
• Coenzile
• Coenzyme B12
• Coenzyme B₁₂
• DBC
• DBC coenzyme
• Dbcc
• Deoxyadenosylcobalamin
• Dibencozide
• Dibenzcozamide
• Dimebenzcozamide
• Dolonevran
• Enzicoba
• Funacomide
• Heraclene
• Hi-Fresmin
• Hycobal
• Indusil
• Lm 176
• Represil
• Sabalamin
• Vitamin B12 coenzyme
• Vitamin B12, Co-(5'-deoxy-5'-adenosyl) deriv.
• Vitamin B₁₂ coenzyme
• Vitamin B₁₂, Co-(5′-deoxy-5′-adenosyl) deriv.
• Xobaline
• α-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
• α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
• coenzyme B12 crystalline
• Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
• adenosyl cobalamine
• 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• DMBC COENZYME
• CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI)
• ADENOSYLCOBALAMINE(COENZYME B12)(P)
• cobalaminecoenzyme
• Coenzyme B
• 2
• ADENOSYLCOBALAMINE(COENZYME B12)(RG)
• 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME
• Cobamamide/VitaminB12
• Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
• 5’-deoxyadenosylvitaminb12
• COBAMIDE
• COBAMAMIDE/DIBENCOZIDE
• DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-
• COBAMAMIDE (PYROGEN FREE)
• cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e
• ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz
• lm176
• ADENOSYLCOBALAMINE(COENZYME B12)(AS)
• 1
• dbccoenzyme
• COENZYME B12, >=97.0%

Adenosylcobalamin

CAS: 13870-90-1

AdoCbl is an active form of vitamin B12, a corrinoid, and cofactor for enzymes like methylmalonyl CoA mutase. Produced by select bacteria/archaea.

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Reinheit: 95.29% - 99.46%

Farbe und Form: Solid

Molekulargewicht: 1579.58

Ref: TM-T14128

Coenzyme B12

CAS: 13870-90-1

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Reinheit: (HPLC) 98.0 - 102.0 % (dried basis)

Farbe und Form: Dark red powder or crystalline powder

Molekulargewicht: 1579.58

Ref: 7W-GP8985

Cobamamide (Dibencozide, Coenzyme B12)

CAS: 13870-90-1

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Farbe und Form: Red Solid

Molekulargewicht: 1579.66

Ref: 4Z-C-161001

Cobamamide

Kontrolliertes Produkt

CAS: 13870-90-1

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Farbe und Form: Neat

Molekulargewicht: 1579.58

Ref: 04-C11692190

Cobamamide

Kontrolliertes Produkt

CAS: 13870-90-1

Applications Cobamamide is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Farbe und Form: Neat

Molekulargewicht: 1579.58

Ref: TR-C633130

Coenzyme B12

CAS: 13870-90-1

Coenzyme B12, also known as vitamin B12, is a coenzyme that participates in the metabolism of amino acids and fatty acids. It is required for the conversion of homocysteine to methionine, which is an important step in the synthesis of S-adenosylmethionine (SAM), a major methyl donor. Coenzymes are required for many different reactions in cells, but they are not consumed during these reactions. Instead, they are regenerated and reused. Coenzyme B12 is synthesized by bacteria and archaea but not by animals. The cobalamin form of this coenzyme is made from cobaltous chloride or cobaltous sulfate and cyanide. This coenzyme has been shown to bind to riboswitches in bacteria and to ATP-binding cassette transporters in humans. Coenzyme B12 can exist in two different forms: adenosylcobalamin and methylcobalamin.

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Reinheit: Min. 97 Area-%

Farbe und Form: Powder

Molekulargewicht: 1,579.58 g/mol

Ref: 3D-FD65841

Cobamamide mono-Ribose13C5

Kontrolliertes Produkt

CAS: 13870-90-1

Applications Isotope labelled Cobamamide (C633130) is an enzyme cofactor that can also regulate gene expression through RNA-base riboswitches.
References Ortiz-Guerrero, J.M., et. al.: P. Natl. Acad. Sci. USA, 108, 7565 (2011)

Formel: C₅C₆₇H₉₉CoN₁₈O₁₇P

Farbe und Form: Neat

Molekulargewicht: 1583.537

Ref: TR-C633132

Coenzyme B12

CAS: 13870-90-1

Coenzyme B12 is a versatile building block in the production of other fine chemicals. It is an important reaction component in research and development, and can also be used as a speciality chemical. Coenzyme B12 has high quality and is used as a reagent in the synthesis of organic compounds.

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Reinheit: Min. 96.0 Area-%

Molekulargewicht: 1,579.58 g/mol

Ref: 3D-W-108227

Cobamamide (5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide)

CAS: 13870-90-1

Vitamin b12 (cyanocobalamin and related compounds with vitamin b12 activity) and its derivatives

Formel: C₇₂H₁₀₀CoN₁₈O₁₇P

Farbe und Form: Powder

Molekulargewicht: 1578.65834

Ref: 45-1142195

Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate),inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3)

CAS: 13870-90-1

Formel: C₇₂H₉₉CoN₁₈O₁₇P

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 1578.5738

Ref: IN-DA01CB8H