CAS 1404-93-9

Vancomycin, Hydrochlorid

Beschreibung:

Vancomycin-Hydrochlorid ist ein glykopeptidisches Antibiotikum, das hauptsächlich zur Behandlung schwerer bakterieller Infektionen eingesetzt wird, insbesondere solcher, die durch grampositive Bakterien verursacht werden, einschließlich methicillinresistenter Staphylococcus aureus (MRSA). Es ist durch seine komplexe Struktur gekennzeichnet, die eine Reihe von Aminosäuren und Zuckermolekülen umfasst, die zu seinem Wirkmechanismus beitragen. Vancomycin wirkt, indem es die Synthese der Zellwand in Bakterien hemmt, was letztendlich zur Zelllyse und zum Zelltod führt. Die Hydrochlorid-Form verbessert seine Löslichkeit in Wasser, was es für die intravenöse Verabreichung geeignet macht. Es wird typischerweise in einem klinischen Umfeld verabreicht, aufgrund seiner Potenz und der Notwendigkeit, potenzielle Nebenwirkungen wie Nephrotoxizität und Ototoxizität zu überwachen. Vancomycin ist auch bemerkenswert für sein Aktivitätsspektrum, das auf bestimmte Bakterienarten beschränkt ist, und wird oft für Fälle reserviert, in denen andere Antibiotika unwirksam sind. Seine Anwendung wird durch Empfindlichkeitstests geleitet, um die Wirksamkeit sicherzustellen und die Entwicklung von Antibiotikaresistenzen zu bekämpfen.

Formel: C₆₆H₇₅Cl₂N₉O₂₄·xClH

InChl: InChI=1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1

InChI Key: InChIKey=LCTORFDMHNKUSG-XTTLPDOESA-N

SMILES: O(C=1C2=CC3=CC1OC=4C(Cl)=CC(=CC4)[C@@H](O)[C@@H](NC([C@@H](CC(C)C)NC)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@]3(C(=O)N[C@@]5(C=6C=C(C=7C([C@@H](C(O)=O)NC(=O)[C@]([C@H](O)C=8C=C(Cl)C(O2)=CC8)(NC5=O)[H])=CC(O)=CC7O)C(O)=CC6)[H])[H])[C@H]9[C@H](O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)[C@@H](O)[C@H](O)[C@@H](CO)O9.Cl

Synonyme:

• (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid hydrochloride (non-preferred name)
• (1S,2R,18R,19R,22S,25R,28R,40S)-48-{[(2S,3R,4S,5S,6R)-3-{[(2S,4S,5S,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2~3,6~.2~14,17~.1~8,12~.1~29,33~.0~10,25~.0~34,39~]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid (non-preferred name)
• (3S-(3R*,6S*(S*),7S*,22S*,23R*,26R*,36S*,38aS*))-3-(2-Amino-2-oxoethyl)-44-((2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-((4-methyl-2-(methylamino)-1-oxopentyl)amino)-2,5,24,38,39-pentaoxo-22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-(1,6,9)oxadiazacyclohexadecino(4,5-m)(10,2,16)benzoxadiazacyclotetracosine-26-carboxylic acid, monohydrochloride
• 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine, vancomycin deriv.
• 48-({3-[(4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl}oxy)-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2~3,6~.2~14,17~.1~8,12~.1~29,33~.0~10,25~.0~34,39~]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid hydrochloride (1:1) (non-preferred name)
• Laikexin
• Lyphocin
• Unii-71Wo621Tjd
• Vancocin hydrochloride
• Vancocine hydrochloride
• Vancocyn
• Vancomycin HCl
• Vancomycin monohydrochloride
• Vancor

Vancomycin hydrochloride, Molecular Biology Grade

CAS: 1404-93-9

Vancomycin hydrochloride, 1404-93-9, is a polypeptide with antibiotic properties suitable for laboratory study of bacterial infections. Learn more at Thermo Fisher Scientific.

Formel: C₆₆H₇₆Cl₃N₉O₂₄

Farbe und Form: White to tan to brown, Free-flowing powder

Molekulargewicht: 1485.72

Ref: 02-J62790

Vancomycin hydrochloride, 50 mg/ml in distilled water, sterile-filtered

CAS: 1404-93-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Ref: 02-J67251

Vancomycin Hydrochloride

CAS: 1404-93-9

Farbe und Form: Neat

Ref: 61-FOR0239.00

SECOND INTERNATIONAL STANDARD FOR VANCOMYCIN

CAS: 1404-93-9

SECOND INTERNATIONAL STANDARD FOR VANCOMYCIN

Formel: C₆₆H₇₅Cl₂N₉O₂₄

Molekulargewicht: 1449.254

Ref: 41-ISA_39036

VANCOMYCIN FOR SYSTEM SUITABILITY CRS

CAS: 1404-93-9

VANCOMYCIN FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0002080

VANCOMYCIN HYDROCHLORIDE CRS

CAS: 1404-93-9

VANCOMYCIN HYDROCHLORIDE CRS

Formel: C₆₆H₇₅Cl₂N₉O₂₄

Farbe und Form: White. Powder.

Molekulargewicht: 1449.254

Ref: 41-V0045000

Vancomycin B with Monodechlorovancomycin

CAS: 1404-93-9

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Formel: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Farbe und Form: Off-White Tan Powder

Molekulargewicht: 1483.40688

Ref: 45-1709018

Vancomycin B

CAS: 1404-93-9

Antibiotics nesoi

Formel: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Farbe und Form: White Brown Powder

Molekulargewicht: 1483.40688

Ref: 45-1709029

Vancomycin, hydrochloride

CAS: 1404-93-9

Formel: C₆₆H₇₆Cl₃N₉O₂₄

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 1485.7145

Ref: IN-DA001CD1

Vancomycin hydrochloride

CAS: 1404-93-9

Vancomycin hydrochloride (Vancomycin HCl) targets peptidoglycan in bacterial cell wall synthesis. High-Quality, Low-Cost!

Formel: C₆₆H₇₆Cl₃N₉O₂₄

Reinheit: 97.20% - 99.19%

Farbe und Form: Off White Powder

Molekulargewicht: 1485.71

Ref: TM-T0832

Vancomycin hydrochloride

CAS: 1404-93-9

Vancomycin hydrochloride

Formel: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Reinheit: Heavy metals: <30 ppm. (Typical Value in Batch COA)

Farbe und Form: white. almost white or tan to brown free flowing powder

Molekulargewicht: 1,485.71g/mol

Ref: 54-BIV0155

Vancomycin hydrochloride, low endotoxin

CAS: 1404-93-9

Formel: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Reinheit: ≤ 5.0%

Farbe und Form: White to tan powder

Molekulargewicht: 1485.73

Ref: 7W-GP4819

Vancomycin hydrochloride

CAS: 1404-93-9

Formel: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Reinheit: ≤ 5.0%

Farbe und Form: White to tan powder

Molekulargewicht: 1485.73

Ref: 7W-GA6284

Vancomycin hydrochloride BioChemica

CAS: 1404-93-9

Vancomycin hydrochloride BioChemica

Farbe und Form: Solid

Molekulargewicht: 1,485.71g/mol

Ref: 54-BIA1839

Vancomycin hydrochloride

Kontrolliertes Produkt

CAS: 1404-93-9

Formel: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Farbe und Form: Neat

Molekulargewicht: 1485.71

Ref: 04-C17900500

Vancomycin Hydrochloride

Kontrolliertes Produkt

CAS: 1404-93-9

Formel: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Farbe und Form: Neat

Molekulargewicht: 1485.71

Ref: 86-MM0239.00

Vancomycin solution

CAS: 1404-93-9

Vancomycin solution

Farbe und Form: Solution

Molekulargewicht: 1,485.71g/mol

Ref: 54-BIG1035

Vancomycin Hydrochloride RS

CAS: 1404-93-9

Farbe und Form: White Solid Powder

Ref: 2K-7000800021

Vancomycin Hydrochloride (90%)

CAS: 1404-93-9

Stability Hygroscopic
Applications Vancomycin Hydrochloride is an antibiotic used against gram-positive bacterial strains.
References Yao, N., et al.: Biopolymers, 90, 421 (2008); Lai, H., et al.: ACS Appl. Mater. Interfaces, 7, 2046 (2015);

Formel: C₆₆H₇₅Cl₂N₉O₂₄·ClH

Reinheit: 90%

Farbe und Form: Neat

Molekulargewicht: 1485.71

Ref: TR-V096533

Vancomycin HCl - pharma grade

CAS: 1404-93-9

Vancomycin is a tricyclic glycopeptide antibiotic that has bactericidal effects against staphylococci, streptococci, and other gram-positive bacteria. It is often used as an alternative treatment for severe staphylococcal and streptococcal infections, including endocarditis, and infections with MRSA (methicillin-resistant Staphylococcus aureus), penicillin-resistant pneumococci or in cases of allergy to penicillins and cephalosporins.

Formel: C₆₆H₇₅Cl₂N₉O₂₄·HCl

Farbe und Form: Powder

Molekulargewicht: 1,485.71 g/mol

Ref: 3D-AV11352

Vancomycin hydrochloride

CAS: 1404-93-9

Inhibitor of cell wall biogenesis; glycopeptide antibiotic

Formel: C₆₆H₇₆Cl₃N₉O₂₄

Reinheit: Min. 88 Area-%

Farbe und Form: Powder

Molekulargewicht: 1,485.71 g/mol

Ref: 3D-AV161115

Vancomycin hydrochloride (1:1)

CAS: 1404-93-9

Vancomycin hydrochloride (1:1) is a glycopeptide antibiotic with action on bacterial cell wall synthesis and is used for treating severe bacterial infections like septicemia, endocarditis, and skin infections.

Formel: C₆₆H₇₆Cl₃N₉O₂₄

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 1,485.72 g/mol

Ref: 3D-XHA63825

Vancomycin hydrochloride, Antibiotic for Culture Media Use Only

CAS: 1404-93-9

Vancomycin hydrochloride is an antibiotic that is used against Gram-positive bacteria, including Staphylococcus aureus. It has been shown to inhibit the growth of bacteria by binding the D-alanyl-D-alanine moiety of the peptidoglycan cell wall precursor, inhibiting the peptidoglycan synthesis and disrupting its cross linking. It also inhibits particle formation when it reacts with human plasma, which can lead to hemolysis and hemagglutination. The absorption spectrum for vancomycin hydrochloride shows maxima at 230, 260, 290, and 320 nm, which are characteristic for this compound. Vancomycin has been used in several studies for treatment of methicillin-resistant Staphylococcus aureus infections.

Formel: C₆₆H₇₆Cl₃N₉O₂₄

Molekulargewicht: 1,485.71 g/mol

Ref: 3D-Q-201920

Vancomycin Hydrochloride (VNC), 90%

CAS: 1404-93-9

Formel: C₆₆H₇₅CI₂N₉O₂₄·HCI

Reinheit: min. 90%

Farbe und Form: Off white to Light pink to Orange brown, Crystalline powder, Clear

Molekulargewicht: 1485.73

Ref: SR-61078