CAS 1424353-63-8

PNR-3-80

CAS: 1424353-63-8

PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.

Formel: C₂₄H₁₄ClN₃O₃S

Farbe und Form: Solid

Molekulargewicht: 459.90

Ref: TM-T212403