CAS 147664-63-9

Pexiganan

Beschreibung:

Pexiganan ist ein synthetisches antimikrobielles Peptid, das hauptsächlich wegen seiner antibakteriellen Eigenschaften, insbesondere gegen gramnegative Bakterien, verwendet wird. Es stammt aus der Familie der Magainin-Peptide, die natürlich in der Haut bestimmter Amphibien vorkommen. Pexiganan zeigt ein breites Spektrum an Aktivitäten, was es effektiv bei der Behandlung von Infektionen macht, insbesondere in topischen Formulierungen für Wunden. Der Wirkmechanismus besteht darin, die bakteriellen Zellmembranen zu stören, was zur Zelllyse führt. Dieses Peptid zeichnet sich durch seine relativ kleine Größe aus, die typischerweise aus etwa 22 Aminosäuren besteht, und seine kationische Natur, die seine Wechselwirkung mit negativ geladenen bakteriellen Membranen verbessert. Pexiganan ist auch bemerkenswert für seine Stabilität und Widerstandsfähigkeit gegen proteolytische Abbau, was zu seiner Wirksamkeit in klinischen Anwendungen beiträgt. Seine Entwicklung konzentrierte sich insbesondere auf die wachsende Besorgnis über Antibiotikaresistenzen und bietet einen alternativen Ansatz zu traditionellen Antibiotikatherapien. Insgesamt stellt Pexiganan einen vielversprechenden Kandidaten im Bereich der antimikrobiellen Mittel dar, insbesondere für die topische Anwendung.

Formel: C₁₂₂H₂₁₀N₃₂O₂₂

InChl: InChI=1/C122H210N32O22/c1-13-77(9)102(152-98(155)71-132)120(174)135-73-100(157)139-86(50-26-35-59-125)110(164)150-96(69-82-44-20-16-21-45-82)118(172)148-93(66-74(3)4)116(170)145-90(54-30-39-63-129)113(167)142-87(51-27-36-60-126)109(163)137-79(11)105(159)141-88(52-28-37-61-127)112(166)143-91(55-31-40-64-130)114(168)149-95(68-81-42-18-15-19-43-81)107(161)134-72-99(156)138-85(49-25-34-58-124)108(162)136-80(12)106(160)147-97(70-83-46-22-17-23-47-83)119(173)153-101(76(7)8)121(175)146-92(56-32-41-65-131)115(169)154-103(78(10)14-2)122(176)151-94(67-75(5)6)117(171)144-89(53-29-38-62-128)111(165)140-84(104(133)158)48-24-33-57-123/h15-23,42-47,74-80,84-97,101-103H,13-14,24-41,48-73,123-132H2,1-12H3,(H2,133,158)(H,134,161)(H,135,174)(H,136,162)(H,137,163)(H,138,156)(H,139,157)(H,140,165)(H,141,159)(H,142,167)(H,143,166)(H,144,171)(H,145,170)(H,146,175)(H,147,160)(H,148,172)(H,149,168)(H,150,164)(H,151,176)(H,152,155)(H,153,173)(H,154,169)/t77-,78-,79-,80-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,101-,102-,103-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](C(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H]([C@@H](C)CC)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(CN)O

Synonyme:

• Pexiganan [INN]
• Glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-L-lysinamide
• Magainin I, 7-L-lysine-8-L-lysine-10-L-lysine-18-L-lysine-19-de-L-glutamic acid-21-L-leucine-23-L-lysinamide
• L-Lysinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylaalanyl-L-valyl-L-lysyl-L-isoleucyl-L-leucyl-L-lysyl-

Pexiganan

CAS: 147664-63-9

Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.

Formel: C₁₂₂H₂₁₀N₃₂O₂₂

Farbe und Form: Solid

Molekulargewicht: 2477.17

Ref: TM-T73653

Pexiganan

CAS: 147664-63-9

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formel: C₁₂₂H₂₁₀N₃₂O₂₂

Molekulargewicht: 2,477.21 g/mol

Ref: 3D-PP50033

Pexiganan acetate

Kontrolliertes Produkt

CAS: 147664-63-9

Pexiganan acetate is the acetate salt form of a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Formel: C₁₂₂H₂₁₀N₃₂O₂₂•(C₂H₄O₂)x

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 2,477.18 g/mol

Ref: 3D-FP182746

Pexiganan

CAS: 147664-63-9

Pexiganan is a polymyxin B derivative that has potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. It has been shown to be effective in the treatment of tissue infections, especially those caused by human pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Pexiganan also has significant activity against Mycobacterium tuberculosis and other mycobacteria. The mechanism of action for pexiganan is not fully understood but it may involve the inhibition of bacterial cell wall synthesis, or the disruption of bacterial membranes. Pexiganan was originally isolated from a marine sponge off the coast of Australia in 1961. It had been classified as an antimicrobial peptide (AMP) because of its chemical structure, which includes a polymyxin B moiety. Pexiganan’s AMP classification was later challenged when researchers found that it did

Formel: C₁₂₂H₂₁₀N₃₂O₂₂

Reinheit: Min. 95%

Molekulargewicht: 2,477.18 g/mol

Ref: 3D-FP138116