CAS 147794-23-8

Omega-Conotoxin mviic

Beschreibung:

Die Omega-Conotoxin MVIIA ist ein Peptid, das aus dem Gift der Conus-Schnecke, speziell Conus magus, gewonnen wird. Es ist ein potenter und selektiver Blocker von spannungsabhängigen Calciumkanälen vom N-Typ (VGCC), die eine entscheidende Rolle bei der Freisetzung von Neurotransmittern und der Schmerzsignalübertragung spielen. Diese Eigenschaft macht die Omega-Conotoxin MVIIA von großem Interesse in der Pharmakologie, insbesondere für ihre potenziellen Anwendungen im Schmerzmanagement und in der neurologischen Forschung. Das Peptid besteht aus einer spezifischen Aminosäuresequenz, die zu seiner einzigartigen Struktur und Funktion beiträgt. Es zeigt eine hohe Affinität zu den N-Typ-Calciumkanälen, hemmt den Calcium-Einstrom und reduziert damit die Freisetzung von Neurotransmittern, was Schmerzen lindern kann. Die Omega-Conotoxin MVIIA wird auch auf ihre potenziellen therapeutischen Wirkungen bei verschiedenen neurologischen Störungen untersucht. Aufgrund ihrer Herkunft aus marinen Organismen stellt sie ein faszinierendes Beispiel dafür dar, wie natürliche Produkte zur Entwicklung neuer pharmazeutischer Wirkstoffe führen können. Ihre Stabilität und Spezifität machen sie zu einem wertvollen Werkzeug sowohl in der Forschung als auch in potenziellen klinischen Anwendungen.

Formel: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Synonyme:

• w-Conotoxin MVIIC, Conus magus
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/ Cys15 and Cys26)
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2 (Disulfide Bridge: 1-16, 8-20, And 15-26)
• Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• Ckgkgapcrktmydccsgscgrrgkc-Nh2 (Disulfide Bridge: 1-16,8-20 And 15-26)
• Omega-Cgtx Mviic
• Omega-Conotoxin Mviic, Conus Magus

ω-Conotoxin MVIIC

CAS: 147794-23-8

Like ω-conotoxin GVIA, this Conus magus peptide inhibits presynaptic Ca²⁺ channels. However, ω-conotoxin MVIIC clearly inhibits additional Ca²⁺ channel subtypes in the mammalian central nervous system. Thus, it should become a standard pharmacological reagent for investigating synaptic transmission in the mammalian nervous system.

Formel: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Reinheit: > 98%

Farbe und Form: White Powder

Molekulargewicht: 2749.29

Ref: 01-4030522

ω-Conotoxin MVIIC

CAS: 147794-23-8

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Formel: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Reinheit: 98%

Farbe und Form: White Lyophilised Solid

Molekulargewicht: 2749

Ref: TM-TP2064

ω-Conotoxin MVIIC

CAS: 147794-23-8

Formel: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Molekulargewicht: 2749.25

Ref: 7W-GK3612

Omega-Conotoxin MVIIC

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide that binds to the nicotinic acetylcholine receptor and activates it, leading to inhibition of neurotransmitter release. It is used as a research tool for studying the pharmacology of ion channels and their ligands. Omega-Conotoxin MVIIC is purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons. CONOTOXINS are small peptides that bind to the nicotinic acetylcholine receptor and activate it, leading to inhibition of neurotransmitter release. They are used as research tools for studying the pharmacology of ion channels and their ligands. CONOTOXINS are purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons.END> END>

Formel: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Reinheit: Min. 95%

Molekulargewicht: 2,749.3 g/mol

Ref: 3D-PCN-4283-S

ω-Conotoxin MVIIC

CAS: 147794-23-8

Omega-conotoxins are a group of peptides found in the venom of predatory marine snails. Omega-conotoxin MVIIC is a potent inhibitor of nicotinic acetylcholine receptors. It blocks the activation and desensitization of nicotinic acetylcholine receptor channels and has been used as a research tool to study the function of these proteins. Omega-conotoxin MVIIC binds to its target by interacting with specific sites on the alpha subunit of nicotinic acetylcholine receptor channels, which leads to inhibition of voltage-gated calcium channels. The high purity and low endotoxin levels make this product suitable for life science research applications.

Formel: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Reinheit: Min. 95%

Molekulargewicht: 2,749.3 g/mol

Ref: 3D-PCN-4283-V

Omega-Conotoxin MVIIC

Kontrolliertes Produkt

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide toxin that blocks the voltage-dependent calcium channels. It has been shown to have neuroprotective properties and to inhibit glutamate induced neurotoxicity in vitro and in vivo. Omega-Conotoxin MVIIC inhibits neurotransmitter release by blocking the calcium channels and thereby reduces oxidative stress, which prevents neuronal cell death. This toxin also blocks the activity of voltage-dependent sodium channels, but its effects are not as potent as those on calcium channels. Omega-Conotoxin MVIIC has been found to be effective against cerebellar granule neurons, as well as other neurons in the brainstem, cerebellum, hippocampus, and cerebral cortex. The molecular weight of this toxin is approximately 10 kDa and it contains subunits (a total of eight).

Formel: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 2,749.26 g/mol

Ref: 3D-FC110353