CAS 14930-96-2

Cytochalasin B

Beschreibung:

Cytochalasin B ist ein natürlich vorkommendes Alkaloid, das aus verschiedenen Pilzarten, insbesondere aus der Gattung *Helminthosporium*, gewonnen wird. Es ist bekannt für seine Fähigkeit, die Polymerisation von Aktin zu hemmen, was die Dynamik des Zytoskeletts stört und die Zellmotilität, -teilung und -form beeinflusst. Diese Verbindung hat eine chemische Formel von C_22H_29N_3O_5 und weist eine komplexe Struktur auf, die einen Laktone-Ring und mehrere funktionelle Gruppen umfasst. Cytochalasin B wird häufig in der biologischen Forschung verwendet, um zelluläre Prozesse zu untersuchen, insbesondere in den Bereichen Zellbiologie und Pharmakologie. Sein Wirkmechanismus besteht darin, an das barbed end der Aktinfilamente zu binden und deren Verlängerung zu verhindern. Darüber hinaus wurde es auf potenzielle therapeutische Anwendungen untersucht, obwohl seine Verwendung hauptsächlich auf Laborumgebungen beschränkt ist, aufgrund seiner zytotoxischen Wirkungen. Sicherheitsvorkehrungen sind beim Umgang mit Cytochalasin B erforderlich, da es erhebliche Auswirkungen auf die Zellfunktionen haben kann und Gesundheitsrisiken darstellen kann, wenn es nicht ordnungsgemäß gehandhabt wird.

Formel: C₂₉H₃₇NO₅

InChl: InChI=1/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22+,23+,24?,26?,27-,29-/m1/s1

InChI Key: InChIKey=GBOGMAARMMDZGR-TYHYBEHESA-N

SMILES: O=C1[C@]23[C@]([C@H](CC4=CC=CC=C4)N1)([C@H](C)C(=C)[C@@H](O)[C@@]2(/C=C/C[C@H](C)CCC[C@@H](O)\C=C\C(=O)O3)[H])[H]

Synonyme:

• (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5S,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (3E,5S,9R,11E,12aS,13S,15S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione
• 10-fenil-7(S),20(R)-dihidroxi-16(R)-metil-24-oxa[14]citochalasa-6(12),13(E),21(E)-trieno-1,23-diona
• 16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
• 24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-
• 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E)-(5S,9R,12aS,13S,15S,15aS,16aS,18aS)-
• 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5R,9R,12aS,13S,15S,15aS,16S,18aS)-
• 2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, [5R-(3E,5R*,9R*,11E,12aS*,13S*,15S*,15aS*,16S*,18aS*)]-
• 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-trien-1,23-dion
• 7,20-Dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-(14)cytochalas-6(12),13,21-trien-23-one
• Brn 1096207
• Ccris 9284
• Hsdb 3479
• Nsc 107658
• Phomin
• Cytochalasin B
• CYTOCHALASIN B SYNTHETIC >97%
• 2h-oxacyclotetradec(2,3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13
• (7s,13e,16r,20r,21e)-0-phenyl
• CYTOCHALICINB
• cytochalasin
• CYTOCHALACINB
• cytochalasin b from drechslera dematioidea
• ,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e)-(
• 9r,12as,13s,15s,15as,16as,18as)-5
• 7,20-dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-[14]cytochalas-6(12),13,21-trien
• ,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2h-oxacyclotetrad
• CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM
• CytochalasinB from Drechslera dematioidea,Phomin
• (E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE
• 9r,12as,13s,15s,15as,16s,18as)--(5
• Cytochalasin B, froM Drechslera deMatoidea
• Cytochalasin beta,helminthosporium dematioideum
• CYTOCHALASIN B FROM HELMINTHOSPORIUM DEMATIODEUM
• Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• CYTOCHALASIN B(RG)
• CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 95.0% (HPLC)
• ,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e,e)
• CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA
• 3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-2h-oxacyclotetradec(
• (e,e)-(5s,9r,12as,13s,15s,15as,16s,18as)-16-benzyl-6,7,8,9,10,12a,13,14,15,15a
• 24-oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione,7,20-dihydroxy-16-methyl-1
• (7S,13E,16R,20R,21E)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,23-dione
• ec[2,3-d]isoindole-2,18(5h)-dione
• (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
• Cytochalasin B from Helminthosporium dematioideum

Cytochalasin B

CAS: 14930-96-2

An actin-disrupting agent

Formel: C₂₉H₃₇NO₅

Farbe und Form: Powder

Molekulargewicht: 479.61

Ref: 02-J65342

Cytochalasin B

CAS: 14930-96-2

Cytochalasin B

Formel: C₂₉H₃₇NO₅

Reinheit: By hplc: 99.35% (Typical Value in Batch COA)

Farbe und Form: white powder

Molekulargewicht: 479.60777g/mol

Ref: 54-BIC1014

Cytochalasin B

CAS: 14930-96-2

Formel: C₂₉H₃₇NO₅

Reinheit: 95%~99%

Molekulargewicht: 479.617

Ref: BP-SBP03783

Cytochalasin B

CAS: 14930-96-2

Formel: C₂₉H₃₇NO₅

Reinheit: (HPLC) ≥ 97.0%

Farbe und Form: White to off-white powder

Molekulargewicht: 479.61

Ref: 7W-GA2080

Cytochalasin B

Kontrolliertes Produkt

CAS: 14930-96-2

Applications Cytochalasin B is a fungal metabolic toxin that preferentially damages malignant cells. Microfilament-disrupting agent which inhibites cytokinesis and produces enlarged neoplastic cells. Apoptotic agent.
References Trendowski, M. et al.: Anticanc. Res., 35, 65 (2015);

Formel: C₂₉H₃₅N₀₅

Farbe und Form: Neat

Molekulargewicht: 477.60

Ref: TR-C998680

Cytochalasin B

CAS: 14930-96-2

Blocker of the actin monomers to the actin filament

Formel: C₂₉H₃₇NO₅

Reinheit: Min. 95%

Farbe und Form: White/Off-White Solid

Molekulargewicht: 479.61 g/mol

Ref: 3D-FC11288

Cytochalasin B

CAS: 14930-96-2

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

Formel: C₂₉H₃₇NO₅

Reinheit: 98.79% - ＞99.99%

Farbe und Form: Felted Needles From Acetone Powder

Molekulargewicht: 479.61

Ref: TM-T7097