CAS 154947-66-7

LL-37

Beschreibung:

LL-37 ist ein menschliches kathelicidin-antimikrobielles Peptid (CAMP), das eine entscheidende Rolle in der angeborenen Immunantwort spielt. Es besteht aus 37 Aminosäuren und ist bekannt für seine breit gefächerte antimikrobielle Aktivität gegen verschiedene Erreger, einschließlich Bakterien, Pilzen und Viren. LL-37 weist eine einzigartige amphipathische Struktur auf, die es ihm ermöglicht, mit mikrobiellen Membranen zu interagieren und diese zu destabilisieren, was zur Zelllyse führt. Darüber hinaus besitzt es immunmodulatorische Eigenschaften, die Entzündungen und Wundheilungsprozesse beeinflussen. LL-37 wird von verschiedenen Zellen produziert, einschließlich Neutrophilen und Epithelzellen, und ist in verschiedenen Geweben zu finden, insbesondere während Infektionen oder Verletzungen. Seine Fähigkeit, Angiogenese zu fördern und Immunantworten zu modulieren, macht es zu einem interessanten Thema in der therapeutischen Forschung, insbesondere im Kontext von chronischen Wunden und Infektionen. Insgesamt ist LL-37 ein wesentlicher Bestandteil des Abwehrsystems des Wirts, der zur Aufrechterhaltung der Integrität von Haut und Schleimhäuten beiträgt.

Synonyme:

• H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
• antibacterial protein LL-37 amide
• LL-37(human)

LL-37

CAS: 154947-66-7

LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.

Formel: C₂₀₅H₃₄₀N₆₀O₅₃

Reinheit: 96.7%

Farbe und Form: White

Molekulargewicht: 4493.33

Ref: 01-4042456

LL-37

CAS: 154947-66-7

Formel: C₂₀₇H₃₄₁F₃N₆₀O₅₅

Reinheit: 98%

Molekulargewicht: 4607.2866

Ref: IN-DA00ATB8

LL-37, Human

CAS: 154947-66-7

LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

Formel: C₂₀₅H₃₄₀N₆₀O₅₃

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 4493.26

Ref: TM-TP1775

LL-37 ( Human)

CAS: 154947-66-7

LL-37 is a 37 amino acid peptide that is produced by neutrophils and other leukocytes. This peptide has been shown to have anti-inflammatory properties, which may be due to its ability to bind and activate the G protein coupled receptor (GPCR) formyl peptide receptor-like 1 (FPRL1), leading to inhibition of the production of inflammatory mediators such as IL-8. LL-37 also binds to ion channels, which may lead to membrane depolarization, thereby blocking calcium influx into the cell. LL-37 has been shown to inhibit the activation of T cells by inhibiting T cell receptor signaling and reducing cytokine production.
LL-37 also has a high affinity for antibody binding sites on B cells and macrophages and can bind with high specificity to IgE on mast cells, leading to inhibition of mast cell degranulation. The binding of LL-37 with these receptors leads to reduced inflammation in tissues, which may

Formel: C₂₀₅H₃₄₀N₆₀O₅₃

Reinheit: Min. 95%

Molekulargewicht: 4,493.3 g/mol

Ref: 3D-PLL-4445-S

Cathelicidin LL 37

CAS: 154947-66-7

LL-37 is a potent antimicrobial peptide that has been shown to be effective against cancer cells and is currently being investigated as a potential antineoplastic agent. LL-37 binds to the leukocyte receptor, which leads to chemotaxis, increased expression of p53 and apoptosis. LL-37 also induces apoptotic cell death in epithelial tissues, both in vitro and in vivo. This peptide has been shown to induce death in cancer cells, as well as cell death in other types of cells.

Formel: C₂₀₅H₃₄₀N₆₀O₅₃

Reinheit: Min. 95%

Molekulargewicht: 4,493.27 g/mol

Ref: 3D-FL110043