CAS 1613031-87-0

6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide

Kontrolliertes Produkt

CAS: 1613031-87-0

Applications 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide is an intermediate in synthesizing T-705RTP (T003210), a derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. T-705RTP which has the triphosphate group, gets strongly inhibited by the influenza virus RNA polymerase activity in comparison with T-705RMP (T003202).
References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010);

Formel: C₈H₁₂FN₃O₂Si

Farbe und Form: Neat

Molekulargewicht: 138.301

Ref: TR-F597083