CAS 163913-87-9

Myelin-Oligodendrozyten-Glykoprotein-Peptidfragment 35-55 Ratte, Maus

Beschreibung:

Das Peptidfragment 35-55 des Myelin-Oligodendrozyten-Glykoproteins (MOG) ist ein synthetisches Peptid, das von der Myelin-Oligodendrozyten-Glykoprotein abgeleitet ist, welches ein bedeutender Bestandteil der Myelinscheide im zentralen Nervensystem ist. Dieses Peptid wird häufig in der Forschung zur Neuroimmunologie und Multipler Sklerose verwendet, da es eine Rolle in der Immunantwort und den Demyelinisierungsprozessen spielt. Die CAS-Nummer 163913-87-9 identifiziert dieses spezifische Peptidfragment, das aus einer Aminosäuresequenz besteht, die in experimentellen Modellen, insbesondere bei Ratten und Mäusen, eine Immunantwort hervorrufen kann. Zu den Eigenschaften dieses Peptids gehört die Fähigkeit, an spezifische Rezeptoren auf Immunzellen zu binden, was potenziell die Aktivierung und Proliferation von T-Zellen beeinflussen kann. Darüber hinaus wird es häufig in Studien verwendet, um die Mechanismen von Autoimmunerkrankungen zu verstehen und therapeutische Strategien zu entwickeln. Seine Stabilität, Löslichkeit und biologische Aktivität sind kritische Faktoren, die Forscher bei der Verwendung dieses Peptids in experimentellen Umgebungen berücksichtigen.

Synonyme:

• MOG 35-55 amide

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), Rat, Mouse

CAS: 163913-87-9

For cellular and molecular biology applications

Formel: C₁₁₈H₁₇₇N₃₅O₂₉S

Molekulargewicht: 2582.0

Ref: 02-J66557

MOG (Rat, Mouse, 35-55)

CAS: 163913-87-9

Amino acids 35-55 derived from the Immunogenic Myelin Oligodendrocyte protein (MOG). Produced by oligodendrocytes, MOG is an integral part of the oligodendrocyte surface membrane, located in the central nervous system (CNS) and plays an important role in the maintenance and disintegration of the myelin sheath. Unique within their immunoglobulin superfamily, MOG is composed of a transmembrane hydrophobic domain, an extracellular immunoglobulin variable (IgV) domain, a short cytoplasmic loop and within the membrane bilayer there is a second hydrophobic region and after this, a cytoplasmic end. In addition to 218 amino acids of the mature MOG protein, it contains a 29 amino acids long signal peptide.
MOG has not only been found to be expressed in the CNS but also at low levels in the peripheral nervous system. Generally MOG is expressed during myelination and functions to maintain the myelin sheath’s structurally integrity through mediating interactions between the myelin and the immune system. This is possible due to its adhesion characteristics and its external location which makes it accessible to antibodies and T-cells. Furthermore is has been suggested that MOG is involved in regulating oligodendrocyte microtubule stability and it can be used as a differentiation marker for oligodendrocyte maturation.Myelin forms a lipid layer around neurons which insulates them. MOG has immunodmainant epitopes: 1-22; 35-55 and 92-106 and this is located at the dimer interface which is formed by MOG IgV domains forming a dimer. These MOG epitopes are recognized by encepalitogenic T cells as foreign antigens. As a result demyelination occurs and this happens in the disease state of Multiple Sclerosis (MS).
As MOG is associated with inflammatory demyelinating diseases within the CNS such as neuromyelitis optica spectrum disorders and acute disseminated encephalomyelitis, this MOG (35-55) product can be used to induce these disease states in animal models.
One-Letter Formula: MEVGWYRSPFSRVVHLYRNGK

Formel: C₁₁₈H₁₇₇N₃₅O₂₉S

Reinheit: Min. 95%

Molekulargewicht: 2,581.95 g/mol

Ref: 3D-PMG-3660-PI

MOG (35-55) acid Mouse, Rat

CAS: 163913-87-9

Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail.  MOG may function as a cell surface receptor or cell adhesion molecule.  Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.The MOG (35-55) fragment is the most potent auto-antigenic region of MOG, and the most effective at inducing experimental autoimmune/allergic encephalomyelitis (EAE), an animal model that resembles MS. This peptide has a free carboxylic acid at the C-terminus, an amide version is also available in our catalogue.

Formel: C₁₁₈H₁₇₇N₃₅O₂₉S

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 2,581.95 g/mol

Ref: 3D-CRB1000205