CAS 1644443-47-9

6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine

CAS: 1644443-47-9

Formel: C₁₄H₁₁ClN₆O₃

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 346.7285

Ref: IN-DA01ENHN

Autophinib

CAS: 1644443-47-9

Autophinib

Reinheit: ≥98%

Molekulargewicht: 346.73g/mol

Ref: 54-BUP05161

Autophinib

CAS: 1644443-47-9

Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and

Formel: C₁₄H₁₁ClN₆O₃

Reinheit: 99.25% - 99.41%

Farbe und Form: Solid

Molekulargewicht: 346.73

Ref: TM-T4219

Autophinib

CAS: 1644443-47-9

Autophinib is a mitochondria-targeted drug that inhibits the mitochondrial membrane potential. It has been shown to suppress tumor growth in human osteosarcoma cells and in carcinoma cell lines by inducing apoptosis, which is mediated by a pathway involving 17β-estradiol, toll-like receptor (TLR) signaling, and autophagy. Autophinib also induces epithelial mesenchymal transition and inhibits autophagy in 17β-estradiol resistant cells. Autophinib is designed to target mitochondria of cancer cells, which are dependent on increased energy metabolism for tumor growth. This drug inhibits the production of reactive oxygen species (ROS) from mitochondria and thus prevents oxidative stress.

Formel: C₁₄H₁₁ClN₆O₃

Reinheit: Min. 95%

Molekulargewicht: 346.73 g/mol

Ref: 3D-UQC44347