CAS 169332-61-0

acetyl-asp-glu-val-asp-7-amido-4-*methylcoumarin

Beschreibung:

Acetyl-asp-glu-val-asp-7-amido-4-methylcoumarin, allgemein als Peptidsubstrat bezeichnet, ist eine synthetische Verbindung, die häufig in der biochemischen Forschung verwendet wird, insbesondere in Studien, die Proteasen und enzymatische Aktivitäten betreffen. Diese Verbindung weist ein Peptidgerüst auf, das aus vier Aminosäuren besteht: Asparaginsäure (Asp), Glutaminsäure (Glu) und Valin (Val), die in einer spezifischen Sequenz miteinander verbunden sind. Die Anwesenheit der 7-amido-4-methylcoumarin-Gruppe dient als fluoreszierende Reportergruppe, die es ermöglicht, enzymatische Reaktionen durch Fluoreszenzmessungen zu überwachen. Diese Eigenschaft macht es besonders wertvoll in Assays für proteolytische Enzyme, bei denen die Spaltung der Peptidbindung das fluoreszierende Signal freisetzt. Die Verbindung ist typischerweise in organischen Lösungsmitteln löslich und zeigt Stabilität unter Standardlaborbedingungen. Ihr Design ermöglicht Spezifität in den Enzym-Substrat-Interaktionen, was sie zu einem nützlichen Werkzeug sowohl in der Grundlagen- als auch in der angewandten Forschung in der Biochemie und Molekularbiologie macht.

Formel: C₃₀H₃₇N₅O₁₃

Synonyme:

• Ac-Asp-Glu-Val-Asp-AMC
• Ac-Devd-Amc

Ac-Asp-Glu-Val-Asp-AMC

CAS: 169332-61-0

A continuous fluorometric assay employing Ac-DEVD-AMC has been developed for the measurement of caspase-3, a cysteine protease also called apopain, Yama or CPP-32. The design of this substrate Ac-DEVD-AMC was based on the substrate motif that has been used successfully with caspase-1, using the poly(ADP-ribose) polymerase cleavage site P₁-P₄ tetrapeptide.

Formel: C₃₀H₃₇N₅O₁₃

Reinheit: 97.3%

Farbe und Form: White Crystalline Powder

Molekulargewicht: 675.65

Ref: 01-4026262

Ac-Asp-Glu-Val-Asp-AMC ammonium salt

CAS: 169332-61-0

Formel: C₃₀H₃₇N₅O₁₃

Reinheit: 97%

Farbe und Form: Solid

Molekulargewicht: 675.6405

Ref: IN-DA01E6VJ

Ac-DEVD-AMC

CAS: 169332-61-0

Ac-DEVD-AMC

Reinheit: ≥98%

Molekulargewicht: 675.64g/mol

Ref: 54-BUP00571

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin

CAS: 169332-61-0

Formel: C₃₀H₃₇N₅O₁₃

Reinheit: (HPLC) ≥ 95.0%

Farbe und Form: Conflicting attributes defined

Molekulargewicht: 675.64

Ref: 7W-GK6157

Ac-DEVD-AMC

CAS: 169332-61-0

Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .

Formel: C₃₀H₃₇N₅O₁₃

Reinheit: 98.20%

Farbe und Form: White Powder

Molekulargewicht: 675.64

Ref: TM-T18909

Ac-Asp-Glu-Val-Asp-AMC ammonium salt

CAS: 169332-61-0

Ac-Asp-Glu-Val-Asp-AMC ammonium salt is a small molecule that is used as a tool to study apoptosis in vitro. Ac-Asp-Glu-Val-Asp-AMC ammonium salt induces apoptosis by blocking the mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytoplasm. This drug also induces activation of caspase 3, which initiates the cascade of events leading to cell death. Ac-Asp-Glu-Val-Asp-AMC ammonium salt has been shown to have an antiangiogenic effect on hl60 cells. This effect may be due to its ability to inhibit expression of survivin, a protein that protects cells from apoptosis. The efficacy of this drug in an experimental model has been shown to be dependent on toll like receptor (TLR) signaling pathways and mitochondrial function.br>

Formel: C₃₀H₃₇N₅O₁₃•NH₃

Reinheit: Min. 97 Area-%

Farbe und Form: Powder

Molekulargewicht: 692.67 g/mol

Ref: 3D-FA110568

Ac-Tyr-Val-Gly

CAS: 169332-61-0

Ac-Tyr-Val-Gly is a mitochondrial protein that regulates mitochondrial functions and is involved in the regulation of apoptosis. Ac-Tyr-Val-Gly interacts with nuclear DNA and regulates transcription, translation, and replication. Ac-Tyr-Val-Gly has been shown to be toxic to liver cells; however, it has been shown to have no effect on neuronal death or apoptosis pathway. These effects may be due to its ability to induce proteolytic activity in neurons and its ability to activate proapoptotic proteins such as Bax.

Formel: C₃₀H₃₇N₅O₁₃

Reinheit: Min. 95%

Molekulargewicht: 675.64 g/mol

Ref: 3D-SYG-3146

Ac-Asp-Glu-Val-Asp-AMC

CAS: 169332-61-0

Ac-Asp-Glu-Val-Asp-AMC is an ion channel activator. It binds to the receptor site of the ligand, which causes a conformational change in the protein that leads to the opening of the ion channel. Ac-Asp-Glu-Val-Asp-AMC is a peptide with a molecular weight of 927.6 and is soluble in water. This product has been shown to be stable under various conditions and can be used as research tool or pharmacological agent. Ac-Asp-Glu-Val-Asp-AMC is also an antibody that binds to an epitope on human CD8 protein and can be used for cell biology studies, such as activation and inhibition of these proteins.

Formel: C₃₀H₃₇N₅O₁₃

Reinheit: Min. 95%

Molekulargewicht: 675.64 g/mol

Ref: 3D-SAP-3171-V