CAS 171228-49-2

Posaconazol

Beschreibung:

Posaconazol ist ein triazolisches Antimykotikum, das hauptsächlich zur Prävention und Behandlung von Pilzinfektionen, insbesondere bei immungeschwächten Patienten, eingesetzt wird. Es zeigt ein breites Wirkungsspektrum gegen verschiedene Pilze, einschließlich Candida- und Aspergillus-Arten. Die chemische Struktur von Posaconazol weist einen Triazolring auf, der entscheidend für seinen Wirkmechanismus ist, da er das Enzym Lanosterol-14α-Demethylase hemmt und die Ergosterolsynthese in Pilzzellmembranen stört. Dies führt zu einer erhöhten Membranpermeabilität und letztendlich zum Zelltod. Posaconazol zeichnet sich durch seine relativ geringe Löslichkeit in Wasser aus, was seine Bioverfügbarkeit beeinträchtigen kann; es ist jedoch in verschiedenen Formulierungen erhältlich, einschließlich oraler Suspensionen und verzögerter Freisetzungstabletten. Das Medikament wird hauptsächlich in der Leber metabolisiert, und seine Pharmakokinetik kann durch Faktoren wie Nahrungsaufnahme und begleitende Medikamente beeinflusst werden. Häufige Nebenwirkungen können gastrointestinale Störungen und Erhöhungen der Leberenzymwerte umfassen. Insgesamt ist Posaconazol eine wichtige therapeutische Option im Management invasiver Pilzinfektionen, insbesondere bei Hochrisikopopulationen.

Formel: C₃₇H₄₂F₂N₈O₄

InChl: InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1

InChI Key: InChIKey=RAGOYPUPXAKGKH-XAKZXMRKSA-N

SMILES: C([C@@]1(C[C@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N([C@H]([C@H](C)O)CC)N=C5)CO1)C6=C(F)C=C(F)C=C6)N7C=NC=N7

Synonyme:

• (2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol
• 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-<span class="text-smallcaps">D</span>-threo-pentitol
• 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
• 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
• <span class="text-smallcaps">D</span>-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
• Hydroxypropyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One
• Noxafil
• Posaconazole SP
• Posaconazole for research
• Sch 56592
• D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-(1-ethyl-2-hydroxypropyl)-2,4-dihydro-, [3R-[3α(1S*,2S*),5α]]-

Posaconazole

CAS: 171228-49-2

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: >98.0%(HPLC)

Farbe und Form: White to Light yellow powder to crystal

Molekulargewicht: 700.79

Ref: 3B-P2477

Posaconazole

CAS: 171228-49-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formel: C₃₇H₄₂F₂N₈O₄

Farbe und Form: White Powder

Molekulargewicht: 700.32971

Ref: 45-1548178

4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

CAS: 171228-49-2

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 700.7774

Ref: IN-DA0039KV

Posaconazole-d5

CAS: 171228-49-2

Formel: C₃₇H₃₇D₅F₂N₈O₄

Farbe und Form: White To Off-White Solid

Molekulargewicht: 705.82

Ref: 4Z-P-382

Posaconazole

CAS: 171228-49-2

Posaconazole

Reinheit: ≥98%

Molekulargewicht: 700.78g/mol

Ref: 54-BUP15078

Posaconazole

CAS: 171228-49-2

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: 98.0 - 102.0 % (dry basis)

Farbe und Form: White to off-white powder

Molekulargewicht: 700.78

Ref: 7W-GP2766

Posaconazole

CAS: 171228-49-2

Formel: C₃₇H₄₂F₂N₈O₄

Farbe und Form: White To Off-White Solid

Molekulargewicht: 700.79

Ref: 4Z-P-381

Posaconazole

CAS: 171228-49-2

Farbe und Form: Neat

Ref: 86-MM3172.00

Posaconazole

CAS: 171228-49-2

Formel: C₃₇H₄₂F₂N₈O₄

Farbe und Form: Neat

Molekulargewicht: 700.78

Ref: 04-C16284800

Posaconazole

CAS: 171228-49-2

Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: 99.72% - >99.99%

Farbe und Form: White Solid

Molekulargewicht: 700.78

Ref: TM-T6211

Posaconazole-13C-15N2

CAS: 171228-49-2

Formel: C₃₆₁₃CH₄₂F₂N₆₁₅N₂O₄

Molekulargewicht: 703.77

Ref: 4Z-P-38102

Posaconazole Impurity 92

CAS: 171228-49-2

Formel: C₁₄H₁₅F₂N₃O₂

Farbe und Form: White To Off-White Solid

Molekulargewicht: 295.29

Ref: 4Z-P-38125

Posaconazole

CAS: 171228-49-2

Formel: C₃₇H₄₂F₂N₈O₄

Farbe und Form: Off-White

Molekulargewicht: 700.78

Ref: TR-P689600

Posaconazole - Bio-X ™

CAS: 171228-49-2

Posaconazole is a triazole antifungal agent that inhibits the 14-alpha demethylase enzyme. This drug prevents the formation of fungal cell walls thus leading to fungal cell lysis. Posaconazole is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species in severely immunocompromised patients.

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: Min. 98 Area-%

Farbe und Form: Powder

Molekulargewicht: 700.78 g/mol

Ref: 3D-BP164281

Posaconazole - Form I

CAS: 171228-49-2

Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: Min. 95%

Molekulargewicht: 700.78 g/mol

Ref: 3D-BP163592

Posaconazole

CAS: 171228-49-2

Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: Min. 98 Area-%

Farbe und Form: White Powder

Molekulargewicht: 700.78 g/mol

Ref: 3D-FP27107

Posaconazole - Form III

CAS: 171228-49-2

Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.

Formel: C₃₇H₄₂F₂N₈O₄

Reinheit: Min. 95%

Molekulargewicht: 700.78 g/mol

Ref: 3D-BP163593

Posaconazole Monodesfluoro

Kontrolliertes Produkt

CAS: 171228-49-2

Formel: C₂₁H₂₂FN₃O₄S

Farbe und Form: Neat

Molekulargewicht: 431.481

Ref: TR-P689645

Posaconazole (Ethyl-d5)

Kontrolliertes Produkt

CAS: 171228-49-2

Formel: C₃₇D₅H₃₇F₂N₈O₄

Farbe und Form: Neat

Molekulargewicht: 705.808

Ref: TR-P689603