CAS 171228-49-2
:Posaconazol
Beschreibung:
Posaconazol ist ein triazolisches Antimykotikum, das hauptsächlich zur Prävention und Behandlung von Pilzinfektionen, insbesondere bei immungeschwächten Patienten, eingesetzt wird. Es zeigt ein breites Wirkungsspektrum gegen verschiedene Pilze, einschließlich Candida- und Aspergillus-Arten. Die chemische Struktur von Posaconazol weist einen Triazolring auf, der entscheidend für seinen Wirkmechanismus ist, da er das Enzym Lanosterol-14α-Demethylase hemmt und die Ergosterolsynthese in Pilzzellmembranen stört. Dies führt zu einer erhöhten Membranpermeabilität und letztendlich zum Zelltod. Posaconazol zeichnet sich durch seine relativ geringe Löslichkeit in Wasser aus, was seine Bioverfügbarkeit beeinträchtigen kann; es ist jedoch in verschiedenen Formulierungen erhältlich, einschließlich oraler Suspensionen und verzögerter Freisetzungstabletten. Das Medikament wird hauptsächlich in der Leber metabolisiert, und seine Pharmakokinetik kann durch Faktoren wie Nahrungsaufnahme und begleitende Medikamente beeinflusst werden. Häufige Nebenwirkungen können gastrointestinale Störungen und Erhöhungen der Leberenzymwerte umfassen. Insgesamt ist Posaconazol eine wichtige therapeutische Option im Management invasiver Pilzinfektionen, insbesondere bei Hochrisikopopulationen.
Formel:C37H42F2N8O4
InChl:InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
InChI Key:InChIKey=RAGOYPUPXAKGKH-XAKZXMRKSA-N
SMILES:C([C@@]1(C[C@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N([C@H]([C@H](C)O)CC)N=C5)CO1)C6=C(F)C=C(F)C=C6)N7C=NC=N7
Synonyme:- (2xi)-1,4-anhydro-2,3,5-trideoxy-4-(2,4-difluorophenyl)-2-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-5-(1H-1,2,4-triazol-1-yl)-D-glycero-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-<span class="text-smallcaps">D</span>-threo-pentitol
- 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
- 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
- <span class="text-smallcaps">D</span>-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- Hydroxypropyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One
- Noxafil
- Posaconazole SP
- Posaconazole for research
- Sch 56592
- D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-(1-ethyl-2-hydroxypropyl)-2,4-dihydro-, [3R-[3α(1S*,2S*),5α]]-
- Weitere Synonyme anzeigen
Sortieren nach
Reinheit (%)
0
100
|
0
|
50
|
90
|
95
|
100
19 Produkte.
Posaconazole
CAS:Formel:C37H42F2N8O4Reinheit:>98.0%(HPLC)Farbe und Form:White to Light yellow powder to crystalMolekulargewicht:700.79Posaconazole
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormel:C37H42F2N8O4Farbe und Form:White PowderMolekulargewicht:700.329714-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one
CAS:Formel:C37H42F2N8O4Reinheit:98%Farbe und Form:SolidMolekulargewicht:700.7774Posaconazole-d5
CAS:Formel:C37H37D5F2N8O4Farbe und Form:White To Off-White SolidMolekulargewicht:705.82Posaconazole
CAS:Formel:C37H42F2N8O4Reinheit:98.0 - 102.0 % (dry basis)Farbe und Form:White to off-white powderMolekulargewicht:700.78Posaconazole
CAS:Posaconazole (POS) is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM).Formel:C37H42F2N8O4Reinheit:99.72% - >99.99%Farbe und Form:White SolidMolekulargewicht:700.78Posaconazole Impurity 92
CAS:Formel:C14H15F2N3O2Farbe und Form:White To Off-White SolidMolekulargewicht:295.29Posaconazole - Bio-X ™
CAS:Posaconazole is a triazole antifungal agent that inhibits the 14-alpha demethylase enzyme. This drug prevents the formation of fungal cell walls thus leading to fungal cell lysis. Posaconazole is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species in severely immunocompromised patients.Formel:C37H42F2N8O4Reinheit:Min. 98 Area-%Farbe und Form:PowderMolekulargewicht:700.78 g/molPosaconazole - Form I
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.Formel:C37H42F2N8O4Reinheit:Min. 95%Molekulargewicht:700.78 g/molPosaconazole - Form III
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Formel:C37H42F2N8O4Reinheit:Min. 95%Molekulargewicht:700.78 g/molPosaconazole Monodesfluoro
CAS:Kontrolliertes ProduktFormel:C21H22FN3O4SFarbe und Form:NeatMolekulargewicht:431.481Posaconazole (Ethyl-d5)
CAS:Kontrolliertes ProduktFormel:C37D5H37F2N8O4Farbe und Form:NeatMolekulargewicht:705.808Posaconazole
CAS:Posaconazole is an antifungal agent that inhibits the 14-alpha demethylase enzyme which is responsible for the synthesis of the fungal cell wall component, ergosterol. This demethylase enzyme synthesizes ergosterol through converting lanosterol to ergosterol. Therefore Posaconazole prevents the formation of fungal cell walls with the appropriate membrane permeability thus leading to fungal cell lysis. Posaconazole can be used as an antifungal drug to treat opportunistic fungal infections in immunocompromised individuals such as HIV patients. Moreover it is shown to inflict its inhibitory activity against common pathogenic fungus such as Candida and Aspergillus species but also Mucorales and some Fusarium species, which are less common.
Formel:C37H42F2N8O4Reinheit:Min. 98 Area-%Farbe und Form:White PowderMolekulargewicht:700.78 g/molRef: 3D-FP27107
Ausgelaufenes produkt
![4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0039KV.jpg&w=3840&q=75)
