CAS 1780390-76-2

Senexin A

CAS: 1780390-76-2

Senexin A is a natural product that has been shown to have anticancer activity in vitro and in vivo. Senexin A was found to inhibit the proliferation of several cancer cell lines, including MDA-MB-231 breast cancer cells. It was also observed to induce apoptosis in these types of cells, which may be due to its ability to block the transcriptional regulation of β-catenin, one of the key proteins involved in tumor progression. Senexin A also inhibits epidermal growth factor (EGF)-induced phosphorylation of extracellular signal regulated kinase 1/2 (ERK1/2) and Akt. Senexin A induces p21 protein expression by increasing the level of transcriptional regulation, leading to cell cycle arrest. In addition, senexin A is an inhibitor for HER2+ breast cancer cells and can be used for diagnostic purposes.

Formel: C₁₇H₁₅ClN₄

Reinheit: Min. 95%

Molekulargewicht: 310.8 g/mol

Ref: 3D-FWC39076

Senexin A hydrochloride

CAS: 1780390-76-2

Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].

Formel: C₁₇H₁₅ClN₄

Farbe und Form: Solid

Molekulargewicht: 310.78

Ref: TM-T84893