CAS 2140-61-6

5-Methylcytidin

Beschreibung:

5-Methylcytidin ist ein Nukleosidderivat der Cytidin, das durch das Vorhandensein einer Methylgruppe an der 5-Position des Pyrimidinrings gekennzeichnet ist. Diese Modifikation spielt eine bedeutende Rolle in verschiedenen biologischen Prozessen, insbesondere bei der Regulation der Genexpression und der RNA-Stabilität. Es kommt häufig in RNA-Molekülen vor, insbesondere in tRNA und rRNA, wo es zur strukturellen Integrität und Funktion dieser essentiellen Biomoleküle beiträgt. Das Vorhandensein der Methylgruppe kann die Interaktion von RNA mit Proteinen und anderen Nukleinsäuren beeinflussen und somit zelluläre Prozesse wie Translation und Transkription beeinflussen. 5-Methylcytidin ist auch an der epigenetischen Regulation beteiligt, da es ein Marker für DNA-Methylierungsmuster sein kann. In Bezug auf die physikalischen Eigenschaften ist es typischerweise ein weißes bis off-white kristallines Feststoff, wasserlöslich und zeigt Stabilität unter physiologischen Bedingungen. Seine chemische Formel ist C₈H₁₁N₃O₅, und es wird in verschiedenen biochemischen und molekularbiologischen Anwendungen eingesetzt, einschließlich Studien zu RNA-Modifikationen und Epigenetik.

Formel: C₁₀H₁₅N₃O₅

InChl: InChI=1S/C10H15N3O5/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)/t5-,6-,7-,9-/m1/s1

InChI Key: InChIKey=ZAYHVCMSTBRABG-JXOAFFINSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C(C)=C2

Synonyme:

• 4-amino-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one
• Cytidine, 5-methyl-
• Nsc 363933
• 5-Methylcytidine
• 3: PN: US20060035254 PAGE: 63 claimed sequence

5-Methylcytidine

CAS: 2140-61-6

Formel: C₁₀H₁₅N₃O₅

Reinheit: >98.0%(T)(HPLC)

Farbe und Form: White to Almost white powder to crystal

Molekulargewicht: 257.25

Ref: 3B-M1931

5-Methylcytidine

CAS: 2140-61-6

Formel: C₁₀H₁₅N₃O₅

Reinheit: 97%

Farbe und Form: Solid

Molekulargewicht: 257.2432

Ref: IN-DA0034AT

5-Methylcytidine

CAS: 2140-61-6

Formel: C₁₀H₁₅N₃O₅

Reinheit: (HPLC) ≥ 98.0%

Farbe und Form: White to almost white powder

Molekulargewicht: 257.24

Ref: 7W-GE4109

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine

Reinheit: ≥95%

Molekulargewicht: 257.24g/mol

Ref: 54-BUP14699

Cytarabine EP Impurity G

CAS: 2140-61-6

Formel: C₁₀H₁₅N₃O₅

Molekulargewicht: 257.25

Ref: 4Z-C-150030

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine

Reinheit: 98%

Molekulargewicht: 257.25g/mol

Ref: 54-OR72458

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine and is a minor constituent of RNA as well as DNA for certain organisms.

Formel: C₁₀H₁₅N₃O₅

Reinheit: 99.02% - 99.88%

Farbe und Form: Solid

Molekulargewicht: 257.24

Ref: TM-T5912

5-Methylcytidine

CAS: 2140-61-6

M02111 - 5-Methylcytidine

Formel: C₁₀H₁₅N₃O₅

Reinheit: 97%

Farbe und Form: Solid, White - Very pale yellow powder

Molekulargewicht: 257.246

Ref: 10-M02111

5-Methylcytidine

Kontrolliertes Produkt

CAS: 2140-61-6

Stability Hygroscopic
Applications 5-Methylcytidine is a derivative of Cytidine (C998300), found in ribonucleic acids of animals, plants and bacteria. 5-Methylcytidine is a nucleoside found in liver emulsion that can inhibit the growth of spontaneous tumors of mammary gland origin in mice. 5-Methylcytidine is one of many nucleosides that can be used as biomedical marker using liquid chromatography and ion trap mass spectrometry coupling.
References Kammerer, B., et al.: Anal. Biol. Chem., 382, 1017 (2005); Strong, L. and Matsunaga, H.: J. Surg. Oncol., 4, 528 (1972)

Formel: C₁₀H₁₅N₃O₅

Farbe und Form: Neat

Molekulargewicht: 257.24

Ref: TR-M294850

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to 5-methylcytosine. This reaction is essential for DNA replication and repair. 5-Methylcytidine has been shown to be an important factor in the regulation of mitochondrial functions, as well as other cellular processes such as protein synthesis, nuclear DNA replication, and tumor suppression. It also has been shown to inhibit the replication of murine sarcoma virus and Toll-like receptor. 5-Methylcytidine can be used in chemotherapy treatment against mouse tumors and murine sarcoma virus by preventing viral RNA synthesis with monoclonal antibodies.

Formel: C₁₀H₁₅N₃O₅

Molekulargewicht: 257.24 g/mol

Ref: 3D-W-201877

Cytarabine EP Impurity G

CAS: 2140-61-6

Formel: C₁₀H₁₅N₃O₅

Molekulargewicht: 257.2

Ref: ST-EA-CP-C163007

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a nucleoside that is found in DNA and RNA. It is used in structural biology to probe the structure of DNA. 5-Methylcytidine binds to the enzyme methyl transferase, which catalyzes the transfer of a methyl group from S-adenosylmethionine to produce 5-methyluridine. This reaction occurs in long-term toxicity studies using primary cells, such as lymphocytes and fibroblasts. 5-Methylcytidine has been shown to inhibit tumour growth in mice by binding to nuclear dna polymerase and blocking transcription. The binding site for this drug on the polymerase is located at the same site as that for nucleoside analogues like azidothymidine (AZT) and zidovudine (AZT).

Formel: C₁₀H₁₅N₃O₅

Reinheit: Min. 95%

Farbe und Form: White Powder

Molekulargewicht: 257.24 g/mol

Ref: 3D-NM03720