CAS 2376068-96-9

SH1573

CAS: 2376068-96-9

SH1573 is an orally active inhibitor of mutant isocitrate dehydrogenase 2 (mIDH2). It selectively targets the mIDH2 R140Q protein with a potent inhibitory effect (IC50=4.78 nmol/L), significantly reducing the production of the oncogenic metabolite 2-hydroxyglutarate (2-HG) in animal models, cell lines, serum, and tumors. SH1573 is utilized in the study of acute myeloid leukemia (AML).

Formel: C₂₁H₁₈F₉N₇O₄S

Farbe und Form: Solid

Molekulargewicht: 635.46

Ref: TM-T200209