CAS 2376399-38-9

4-Oxazolecarboxamide, N-[5-[(3R)-3-hydroxy-1-pyrrolidinyl]-2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl]-2-(2-methyl-4-pyridinyl)-, phosphate (1:1)

Formel: C₂₄H₂₅N₇O₅·H₃O₄P

Synonyme:

• [Synonyms]

Emavusertib Phosphate

CAS: 2376399-38-9

Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.

Formel: C₂₄H₂₈N₇O₉P

Molekulargewicht: 589.49

Ref: TM-T202829