CAS 25126-32-3

(27-tyr(so(3)H))cholecystokinin-Fragment (26-33)-amid

Beschreibung:

Die chemische Substanz, die als "(27-tyr(so(3)H))cholecystokinin-Fragment (26-33)-amid" bekannt ist, mit der CAS-Nummer 25126-32-3, ist ein Peptidfragment, das von Cholezystokinin (CCK) abgeleitet ist, einem Hormon, das an der Verdauung und Sättigung beteiligt ist. Dieses spezifische Fragment besteht aus den Aminosäuren 26 bis 33 des CCK-Moleküls, mit einer sulfatierte Tyrosin an Position 27, die entscheidend für seine biologische Aktivität ist. Die Anwesenheit der Sulfatgruppe verbessert die Wechselwirkung des Peptids mit seinen Rezeptoren und beeinflusst verschiedene physiologische Prozesse wie die Kontraktion der Gallenblase und die Sekretion von Enzymen aus der Bauchspeicheldrüse. Die Struktur dieses Peptids umfasst eine Sequenz von Aminosäuren, die durch Peptidbindungen verbunden sind, und es zeigt typische Eigenschaften von Peptiden, wie Löslichkeit in Wasser und Stabilität unter physiologischen Bedingungen. Seine biologische Bedeutung wird durch seine Rolle im gastrointestinalen System unterstrichen, was es zu einem interessanten Thema in Studien über Verdauung, Appetitregulation und potenzielle therapeutische Anwendungen bei gastrointestinalen Störungen macht.

Formel: C₄₉H₆₂N₁₀O₁₆S₃

InChl: InChI=1/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1

SMILES: CSCC[C@@H](C(=NCC(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCSC)C(=N[C@@H](CC(=O)O)C(=N[C@@H](Cc1ccccc1)C(=N)O)O)O)O)O)O)N=C([C@H](Cc1ccc(cc1)OS(=O)(=O)O)N=C([C@H](CC(=O)O)N)O)O

Synonyme:

• (tyr(so3H)27)-cholecystokinin fragment*26-33 amid
• Sincalide
• Cholecystokinin Octapeptide
• Tyr(SO3H]27)Cholecystokinin fragment 26-33 Amide
• alpha-aspartyl-O-sulfotyrosylmethionylglycyltryptophylmethionyl-alpha-aspartylphenylalaninamide
• L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
• Sincalide(CCK-8)
• Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
• Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-
• Cholecystokinin C-terminal octapeptide
• Cholecystokinin octapeptide (26-33 sulfated)
• Cholecystokinin-(26-33)-amide
• Cholecystokinin-8 (chicken)
• Cholecystokinin-8 (pig)
• Cholecystokinin-8 (Squalus acanthias)
• Cholecystokinin-8 (swine)
• Cholecystokinin-pancreozymin (swine intestine C-terminal octapeptide)
• Cholecystokinin-pancreozymin C-terminal octapeptide
• Human CCK-8
• L-Phenylalaninamide, L-α-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
• Sincalid
• Sincalida

Cholecystokinin, CCK Octapeptide (26-33)

CAS: 25126-32-3

For cellular and molecular biology applications

Farbe und Form: White, Lyophilized Powder

Ref: 02-J66669

Cholecystokinin Octapeptide (sulfated)

CAS: 25126-32-3

CCK-8 exhibits various gastrointestinal effects as contraction of the gallbladder and stimulation of pancreatic secretion and gastrointestinal transit. In rats, CCK-8 facilitated the uptake of leptin from peripheral circulation to cerebrospinal fluid and its access to the hypothalamus.

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Reinheit: 98.42%

Farbe und Form: White Powder

Molekulargewicht: 1143.29

Ref: 01-4033010

3-10-Caerulein, 5-L-methionine-

CAS: 25126-32-3

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Reinheit: 97%

Farbe und Form: Solid

Molekulargewicht: 1143.2690

Ref: IN-DA002QKR

Sincalide

CAS: 25126-32-3

Sincalide

Reinheit: ≥98%

Molekulargewicht: 1143.27g/mol

Ref: 54-BUP02057

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

CAS: 25126-32-3

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Molekulargewicht: 1143.27

Ref: 7W-GL1683

Sincalide

CAS: 25126-32-3

Sincalide

Farbe und Form: Powder

Molekulargewicht: 1,143.27g/mol

Ref: 54-BITH3042

Sincalide(CCK-8)

CAS: 25126-32-3

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Reinheit: 95%~99%

Farbe und Form: White to Off-white Powder

Molekulargewicht: 1143.27

Ref: BP-BPPG057

Sincalide

CAS: 25126-32-3

Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Reinheit: 98.32%

Farbe und Form: Solid

Molekulargewicht: 1143.27

Ref: TM-TP1197

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

CAS: 25126-32-3

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 is a versatile building block that can be used in research on complex compounds, fine chemicals, speciality chemicals and reagents. It is a high quality chemical that can be used as an intermediate or a scaffold. Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe NH2 is soluble in water and has a high degree of solubility in organic solvents. The compound is also stable under acidic conditions.

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Reinheit: Min. 98.0 Area-%

Molekulargewicht: 1,143.27 g/mol

Ref: 3D-W-107263

Sincalide

CAS: 25126-32-3

Sincalide is a cholecystokinin (CCK) analog that has been used as a pharmacological agent. It is an agonist for CCK-A receptors and inhibits the activity of protein kinase C. Sincalide also has been shown to suppress tumor growth in experimental models. A polymerase chain reaction analysis of cck-8, a rat CCK receptor gene, showed a high degree of homology with human CCK-A receptor genes. The physiological effects of sincalide are complex and depend on the presence or absence of other hormones such as insulin, glucagon, somatostatin, and leptin.

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 1,143.27 g/mol

Ref: 3D-FS41124

CCK-Octapeptide (26-33) (Sulfated Form)

CAS: 25126-32-3

CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther

Formel: C₄₉H₆₂N₁₀O₁₆S₃

Reinheit: Min. 95%

Molekulargewicht: 1,143.3 g/mol

Ref: 3D-PCK-4100-V