CAS 251293-28-4

L-Valin, L-a-glutamyl-L-threonyl-L-prolyl-L-a-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-,zyklisch (5®10)-disulfid

Beschreibung:

L-Valin, L-a-Glutamyl-L-Threonyl-L-Prolyl-L-a-Aspartyl-L-Cysteinyl-L-Phenylalanin-L-Tryptophan-L-Lysin-L-Tyrosin-L-Cysteinyl-, zyklisch (5®10)-Disulfid, identifiziert durch die CAS-Nummer 251293-28-4, ist ein zyklisches Peptid, das aus mehreren Aminosäuren besteht. Diese Verbindung weist eine zyklische Struktur auf, die durch eine Disulfidbindung zwischen zwei Cystein-Resten gebildet wird, was zu ihrer Stabilität und einzigartigen Eigenschaften beiträgt. Das Vorhandensein verschiedener Aminosäuren, einschließlich Valin, Glutamat, Threonin, Prolin, Asparagin, Cystein, Phenylalanin, Tryptophan, Lysin und Tyrosin, deutet darauf hin, dass es vielfältige biologische Aktivitäten aufweisen könnte, die potenziell Proteininteraktionen und Zellfunktionen beeinflussen. Die zyklische Natur des Peptids kann seine Widerstandsfähigkeit gegen enzymatische Abbau erhöhen, was es zu einem Kandidaten für therapeutische Anwendungen macht. Darüber hinaus kann die spezifische Anordnung der Aminosäuren einzigartige konformationale Eigenschaften verleihen, die seine Löslichkeit, Bindungsaffinität und allgemeine Bioaktivität beeinflussen. Weitere Studien wären erforderlich, um seine genauen Funktionen und potenziellen Anwendungen in der Biochemie oder Medizin zu klären.

Formel: C₆₄H₈₅N₁₃O₁₈S₂

Synonyme:

• 1:PN: JP2002087982 PAGE: 2 claimed protein
• 47: PN: WO0031265 SEQID: 3 claimedprotein
• Human urotensin II
• Urotensin II (human)
• H-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (Disulfide bond)

Urotensin II (human)

CAS: 251293-28-4

Urotensin II is a vasoactive somatostatin-like cyclic peptide, which has long been regarded as a peptide exclusively produced by the urophysis of teleost fish. U-II has also been cloned from man. It was found to be the most potent mammalian vasoconstrictor identified so far. Furthermore, as urotensin II immunoreactivity was also found within central nervous system and endocrine tissues, it may have additional activities.

Formel: C₆₄H₈₅N₁₃O₁₈S₂

Reinheit: ≥ 95%

Farbe und Form: White Powder

Molekulargewicht: 1388.59

Ref: 01-4029364

Urotensin II (114-124), human

CAS: 251293-28-4

Human Urotensin II (114-124) is an 11-amino acid peptide with vasoconstrictor properties and agonizes GPR14.

Formel: C₆₄H₈₅N₁₃O₁₈S₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 1388.57

Ref: TM-TP1737

Urotensin II (Human)

CAS: 251293-28-4

A potent vasoconstrictor, available in the hydrochloride form with disulfide bonds between Cys5-Cys10 and as a 0.5mg vial.
Urotensin II (UT-II) is a peptide that is found in humans and other vertebrates and is involved in biological systems such as the nervous, endocrine, cardiovascular and renal.
Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function. Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.
UT-II is widely distributed throughout the body, with highest concentrations found in the cardiovascular system, particularly in the heart and blood vessels. UT-II has been shown to have a wide range of physiological effects in humans, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin. 
In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.

Formel: C₆₄H₈₅N₁₃O₁₈S₂

Reinheit: Min. 95%

Molekulargewicht: 1,388.6 g/mol

Ref: 3D-PUT-4365-V