CAS 26305-03-3

Pepstatin A ~120'000 U/mg

Beschreibung:

Pepstatin A ist ein potenter und selektiver Inhibitor von aspartischen Proteasen, insbesondere Renin und Pepsin, und wird aus der Fermentation bestimmter Arten des Bakteriums *Streptomyces* gewonnen. Sie zeichnet sich durch ihre einzigartige Struktur aus, die ein Peptidgerüst mit einer spezifischen Sequenz umfasst, die es ihr ermöglicht, effektiv an die aktiven Stellen der Zielenzyme zu binden und deren Aktivität zu hemmen. Die Substanz hat ein Molekulargewicht von etwa 1.000 Da und wird häufig in der biochemischen Forschung verwendet, um proteolytische Prozesse und Enzymkinetik zu untersuchen. Pepstatin A zeigt eine hohe Spezifität und Affinität für aspartische Proteasen, was sie zu einem wertvollen Werkzeug sowohl in der Grundlagen- als auch in der angewandten Forschung macht, einschließlich Studien zur Proteinverdauung und -regulation. Ihre Wirksamkeit wird oft in Inhibitionseinheiten quantifiziert, wie "120.000 U/mg", was ihre Potenz anzeigt. Darüber hinaus ist es wichtig, Pepstatin A mit Vorsicht zu behandeln, da sie biologische Wirkungen haben kann, und geeignete Lagerbedingungen erforderlich sind, um ihre Stabilität und Aktivität zu erhalten.

Formel: C₃₄H₆₃N₅O₉

InChl: InChI=1/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23+,24-,25-,26+,30-,31-/m1/s1

Synonyme:

• Pepstatin A
• pepstatin A from microbial source
• Pepstatin (microbial product)
• Isovaleryl-Val-Val-Sta-Ala-Sta-OH
• N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide
• (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid
• Pepstatin

Pepstatin A

CAS: 26305-03-3

Pepstatin A (isovaleryl-pepstatin), a low molecular weight inhibitor of acid proteases, e.g. pepsin, renin, cathepsin D, and plasmepsin II. For the Plasmodium falciparum aspartyl protease plasmepsin II, Hill et al determined an IC₅₀ of 0.1 nM.

Formel: C₃₄H₆₃N₅O₉

Reinheit: > 99%

Farbe und Form: White Powder

Molekulargewicht: 685.9

Ref: 01-4031136

Pepstatin

CAS: 26305-03-3

Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.

Formel: C₃₄H₆₃N₅O₉

Reinheit: 96.74% - 99.94%

Farbe und Form: Solid

Molekulargewicht: 685.89

Ref: TM-T3695

L-Alaninamide,N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-

CAS: 26305-03-3

Formel: C₃₄H₆₃N₅O₉

Reinheit: 75%

Farbe und Form: Solid

Molekulargewicht: 685.8921

Ref: IN-DA00I50B

Pepstatin A

CAS: 26305-03-3

Pepstatin A

Formel: C₃₄H₆₃N₅O₉

Reinheit: By hplc: 98.2% (220 nm) (Typical Value in Batch COA)

Farbe und Form: white to off white powder

Molekulargewicht: 685.89212g/mol

Ref: 54-BIMI2205

Pepstatin

CAS: 26305-03-3

Pepstatin

Reinheit: ≥95%

Molekulargewicht: 685.89g/mol

Ref: 54-BUP16261

Pepstatin A

CAS: 26305-03-3

Formel: C₃₄H₆₃N₅O₉

Reinheit: >90.0%(HPLC)

Farbe und Form: White to Light yellow powder to crystal

Molekulargewicht: 685.90

Ref: 3B-P3041

Pepstatin A

CAS: 26305-03-3

Formel: C₃₄H₆₃N₅O₉

Molekulargewicht: 685.90

Ref: 4Z-P-470001

Pepstatin A

CAS: 26305-03-3

Formel: C₃₄H₆₃N₅O₉

Reinheit: ≥ 98.0%

Farbe und Form: White to off-white powder

Molekulargewicht: 685.90

Ref: 7W-GE3524

Pepstatin A (Purity Higher than 90% by HPLC)

CAS: 26305-03-3

Pepstatin A is a natural product that inhibits the activity of proteases, particularly chymotrypsin and trypsin. It binds to the active site of these enzymes, blocking access to their substrate. Pepstatin A has been shown to have synergistic effects with other drugs in vitro, such as dapsone and clindamycin. Pepstatin A has inhibitory properties against infectious diseases, including HIV-1 and HIV-2, influenza virus type A (H1N1), herpes simplex virus type 1 (HSV-1), human papilloma virus type 18 (HPV-18), hepatitis C virus (HCV) types 1a and 1b, as well as dengue fever virus. Pepstatin A is also effective in inhibiting polymerase chain reaction amplification of mitochondrial DNA from patients with mitochondrial disorders. The biological sample for this research was obtained from calf thymus tissue. The natural compound pepstatin A has

Formel: C₃₄H₆₃N₅O₉

Reinheit: Higher Than 90% By Hplc)

Molekulargewicht: 685.89 g/mol

Ref: 3D-IPA-4397

Pepstatin A (Synthetic)

CAS: 26305-03-3

Pepstatin A is a natural product that has been synthesized for use as an inhibitor of proteolytic enzymes. It inhibits the activity of a wide range of proteases and is used in vitro to study the biochemical properties of these enzymes. Pepstatin A inhibits the activity of many important proteases, including those involved in infectious diseases, such as HIV and hepatitis C virus. Pepstatin A binds to the active site on serine proteases, blocking access by their substrates and thereby inhibiting enzyme activity. The binding site is highly conserved among different types of serine protease, with approximately 90% homology between trypsin and chymotrypsin. The inhibitory mechanism involves a specific interaction between pepstatin A's hydrophobic side chain and the catalytic triad residues His57, Asp102, and Ser195 in trypsin or His57, Asp102, and Ser188 in chymotrypsin.

Formel: C₃₄H₆₃N₅O₉

Reinheit: Min. 95%

Molekulargewicht: 685.89 g/mol

Ref: 3D-IPA-3998-PI

Pepstatin A

CAS: 26305-03-3

Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments.

Molekulargewicht: 685.89 g/mol

Ref: 3D-CRB1001649