CAS 2810809-10-8

Cyclopropanecarboxamide, N-[5-[2-cyano-5-[[(3R)-1-methyl-3-pyrrolidinyl]methoxy]-4-pyridinyl]pyrazolo[1,5-a]pyridin-2-yl]-

Formel: C₂₃H₂₄N₆O₂

Synonyme:

• Cyclopropanecarboxamide, N-[5-[2-cyano-5-[[(3R)-1-methyl-3-pyrrolidinyl]methoxy]-4-pyridinyl]pyrazolo[1,5-a]pyridin-2-yl]-

SIK2-IN-3

CAS: 2810809-10-8

SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 μM. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.

Formel: C₂₃H₂₄N₆O₂

Farbe und Form: Solid

Molekulargewicht: 416.48

Ref: TM-T207716