CAS 2878473-51-7

ATM Inhibitor-11

CAS: 2878473-51-7

ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.

Formel: C₂₇H₃₃FN₆O₂

Farbe und Form: Solid

Molekulargewicht: 492.59

Ref: TM-T201457