CAS 290371-78-7

3'-Deoxy-5'-O-DMT-3'-fluoro-thymidine

CAS: 290371-78-7

3'-Deoxy-5'-O-DMT-3'-fluoro-thymidine (3'DFT) is a nucleoside that can be used as an anticancer drug. It is synthesized by the replacement of the 3'-hydroxyl group with a fluorine atom in 5'-O-DMT-3'-fluoro-thymidine. The synthesis of 3'DFT starts with the reaction of 5'O-(4,4'-dimethoxytrityl)-3'-deoxyuridine and 1,2,4,5-tetraisopropyldiazoacetate to form 5'O-(4,4'-dimethoxytrityl)-3'-deoxythymidine. This is followed by a reduction of the ester group to produce 5'O-(4,4'dimethoxytrityl)-3'F-thymidine. An acetate group is then added to

Formel: C₃₁H₃₁FN₂O₆

Reinheit: Min. 95%

Molekulargewicht: 546.59 g/mol

Ref: 3D-ND97314