CAS 2991817-99-1

3-(5-amino-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)piperidine-2,6-dione

Formel: C₁₄H₁₆N₄O₃

Synonyme:

• 3-(5-amino-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)piperidine-2,6-dione
• 2,6-Piperidinedione, 3-(5-amino-3,4-dihydro-3-methyl-1-oxo-2(1H)-phthalazinyl)-

MGD-4

CAS: 2991817-99-1

MGD-4 is an orally active, Cereblon (CRBN)-dependent degrader of IKAROS proteins that demonstrates dose-dependent degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM). The compound effectively inhibits the growth of multiple myeloma.

Formel: C₁₄H₁₆N₄O₃

Molekulargewicht: 288.3

Ref: TM-T201701