CAS 3037216-20-6

Tuspetinib dihydrochloride

CAS: 3037216-20-6

Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis).

Formel: C₂₉H₃₅Cl₃N₆

Farbe und Form: Solid

Molekulargewicht: 573.99

Ref: TM-T212318