CAS 3043908-63-7

PROTAC pan-KRAS degrader-1

CAS: 3043908-63-7

PROTACpan-KRAS degrader-1 is a pan-KRAS PROTAC degrader that targets multiple KRAS mutants, including G12D, G12C, G12V, and G13D. It effectively degrades the KRAS mutant (G12D) in AGS cells, with a DC50 of 1.1 nM and a Dmax of 95%. This compound can be used in studies of diseases caused by KRAS mutations or amplifications, particularly in cancers such as breast, bladder, and gastric cancer.

Formel: C₆₃H₇₁F₂N₁₃O₇S

Farbe und Form: Solid

Molekulargewicht: 1192.38

Ref: TM-T211239