CAS 3058911-16-0

DeFer-2

CAS: 3058911-16-0

DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.

Formel: C₄₄H₆₉N₅O₅S

Farbe und Form: Solid

Molekulargewicht: 780.11

Ref: TM-T212081