CAS 3106-85-2

N-Acetylaspartylglutaminsäure

Beschreibung:

N-Acetylaspartylglutaminsäure, allgemein bekannt als NAAG, ist ein natürlich vorkommendes Dipeptid, das aus den Aminosäuren N-Acetylaspartat und Glutamat besteht. Es wird als Neurotransmitter klassifiziert und spielt eine bedeutende Rolle im zentralen Nervensystem, insbesondere bei der Modulation der synaptischen Übertragung und der Neuroprotektion. NAAG ist bekannt dafür, auf metabotrope Glutamatrezeptoren zu wirken und verschiedene physiologische Prozesse zu beeinflussen, einschließlich der Schmerzempfindung und der Neuroplastizität. Die Substanz ist in Wasser löslich und zeigt Stabilität unter physiologischen Bedingungen, was sie für die Forschung in der Neurobiologie und potenzielle therapeutische Anwendungen relevant macht. Ihre CAS-Nummer, 3106-85-2, wird zur Identifizierung in chemischen Datenbanken verwendet. Das Engagement von NAAG bei neurodegenerativen Erkrankungen und sein Potenzial als Biomarker für bestimmte neurologische Bedingungen sind Bereiche der laufenden Forschung, die seine Bedeutung in den Grundlagen- und angewandten Wissenschaften hervorheben.

Formel: C₁₁H₁₆N₂O₈

InChl: InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

InChI Key: InChIKey=OPVPGKGADVGKTG-BQBZGAKWSA-N

SMILES: [C@@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)(CC(O)=O)NC(C)=O

Synonyme:

• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-(N-acetyl-<smallcap>L</span>-α-aspartyl)-
• <span class="text-smallcaps">L</smallcap>-Glutamic acid, N-acetyl-<smallcap>L</span>-α-aspartyl-
• Ac-Asp-Glu-OH
• Acetyl-α-<span class="text-smallcaps">L</span>-aspartylglutamic acid
• Glutamic acid, N-(N-acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl)-, <smallcap>L</span>-
• Isospaglumic Acid
• N-(N-Acetylaspartyl)glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-<span class="text-smallcaps">L</smallcap>-α-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-<span class="text-smallcaps">L</smallcap>-aspartyl-<smallcap>L</span>-glutamic acid
• N-Acetyl-α-aspartylglutamic acid
• N-Acetylaspartylglutamic acid
• N-acetyl-D-alpha-aspartyl-L-glutamic acid
• N-acetyl-L-alpha-aspartyl-L-glutamic acid
• N-acetyl-alpha-aspartylglutamic acid
• α-Spaglumic acid
• L-Glutamic acid, N-acetyl-L-α-aspartyl-
• Glutamic acid, N-(N-acetyl-L-aspartyl)-, L-
• N-Acetyl-L-α-aspartyl-L-glutamic acid

Ac-Asp-Glu-OH

CAS: 3106-85-2

An endogenous dipeptide with high affinity for a brain glutamate receptor. NAAG is the most abundant peptide neurotransmitter in the mammalian central nervous system.

Formel: C₁₁H₁₆N₂O₈

Reinheit: > 99%

Farbe und Form: White Powder

Molekulargewicht: 304.26

Ref: 01-4006232

L-Glutamic acid, N-acetyl-L-α-aspartyl-

CAS: 3106-85-2

Formel: C₁₁H₁₆N₂O₈

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 304.2533

Ref: IN-DA00321K

N-Acetyl-Asp-Glu

CAS: 3106-85-2

Formel: C₁₁H₁₆N₂O₈

Reinheit: ≥ 95.0%

Farbe und Form: White to off-white powder

Molekulargewicht: 304.25

Ref: 7W-GL2335

Spaglumic acid

CAS: 3106-85-2

Spaglumic acid

Reinheit: ≥95%

Molekulargewicht: 304.25g/mol

Ref: 54-BUP14509

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

CAS: 3106-85-2

(S)-2-((S)-2-Acetamido-3-Carboxypropanamido)Pentanedioic Acid

Reinheit: 95%

Molekulargewicht: 304.25g/mol

Ref: 54-OR1024085

Spaglumic acid

CAS: 3106-85-2

Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in the brain.

Formel: C₁₁H₁₆N₂O₈

Reinheit: 99.92%

Farbe und Form: White Powder

Molekulargewicht: 304.25

Ref: TM-TQ0285

Spaglumic Acid-d3

Kontrolliertes Produkt

CAS: 3106-85-2

Stability Hygroscopic
Applications Spaglumic Acid-d3 is the isotope labelled analogue of Spaglumic Acid, a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Formel: C₁₁H₁₃D₃N₂O₈

Farbe und Form: Neat

Molekulargewicht: 307.27

Ref: TR-S679102

N-Acetyl-L-aspartyl-L-glutamic acid

CAS: 3106-85-2

N-Acetyl-L-aspartyl-L-glutamic acid is an amino acid that is used as a substrate in the biochemical assay for glutamate. It is also used to measure brain functions. NAAG is a low potency agonist of the NMDA receptor, which may contribute to neuronal death. NAAG is used as a model system to study bowel disease and eosinophil cationic protein. It has been shown to be effective in vitro against cancer cells and fungi. The structural analysis of NAAG has revealed that it contains an acidic group on its side chain, which can be detected with a pH indicator such as phenol red or bromocresol purple.

Formel: C₁₁H₁₆N₂O₈

Reinheit: Min. 95 Area-%

Farbe und Form: White Off-White Powder

Molekulargewicht: 304.25 g/mol

Ref: 3D-FA05316

Spaglumic Acid

Kontrolliertes Produkt

CAS: 3106-85-2

Applications Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);

Formel: C₁₁H₁₆N₂O₈

Farbe und Form: Neat

Molekulargewicht: 304.25

Ref: TR-S679100

Ac-Asp-Glu • H2O

CAS: 3106-85-2

Ac-Asp-Glu • H2O is a water soluble molecule that belongs to the class of inhibitors. It has been shown to inhibit the polymerase chain reaction and is used as an analytical method for detecting DNA sequences. Ac-Asp-Glu • H2O induces neuronal death in the caudate putamen, thereby causing bowel disease, by inhibiting energy metabolism. This compound also inhibits the synthesis of proteins in the hippocampus, which leads to reduced locomotor activity and eosinophil cationic protein production. Ac-Asp-Glu • H2O is acidic and its concentration–time curve shows a bell shape. The half life of this compound is six hours.

Formel: C₁₁H₁₆N₂O₈•H₂O

Reinheit: Min. 95%

Molekulargewicht: 322.28 g/mol

Ref: 3D-PDE-4167