CAS 315-22-0
:Monocrotalin
Beschreibung:
Monocrotalin ist ein natürlich vorkommendes Alkaloid, das hauptsächlich aus der Pflanzenart *Crotalaria* gewonnen wird und für seine toxischen Eigenschaften bekannt ist. Es gehört zur Klasse der Pyrrolizidinalkaloide, die durch eine bicyclische Struktur mit einem Pyrrolizidingring gekennzeichnet sind. Monocrotalin zeigt Hepatotoxizität und kann pulmonale Hypertonie verursachen, was es zu einem interessanten Thema in der Toxikologie und Pharmakologie macht. Es ist bekannt, dass die Verbindung eine metabolische Aktivierung in der Leber durchläuft, die zur Bildung reaktiver Metaboliten führt, die Zellstrukturen, insbesondere in der Leber und in den Lungen, schädigen können. Sein Wirkmechanismus umfasst die Bildung von DNA-Addukten, die mutagene Effekte zur Folge haben können. Aufgrund seiner toxischen Natur wird Monocrotalin häufig im Kontext von Umweltgesundheit und -sicherheit untersucht, insbesondere in Bezug auf Expositionsrisiken, die mit bestimmten Pflanzen verbunden sind. Darüber hinaus wurde es in der Forschung verwendet, um pulmonale Hypertonie in Tierstudien zu modellieren, was Einblicke in die Krankheitsmechanismen und potenzielle therapeutische Ansätze bietet.
Formel:C16H23NO6
InChl:InChI=1/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/p+1/t9-,11+,12+,15+,16-/m0/s1
InChI Key:InChIKey=QVCMHGGNRFRMAD-XFGHUUIASA-N
SMILES:O=C1O[C@]2([C@@]3(N(CC2)CC=C3COC(=O)[C@](C)(O)[C@](C)(O)[C@H]1C)[H])[H]
Synonyme:- (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione
- (2,3,4-gh)pyrrolizine-2,6(3H)-dione, (4,5,8,10,12,13,13a,13b)-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino-
- (3R,4R,5R,13aR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3R,4R,5R,13aR,13bR)-4,5,8,10,12,13,13a,13b-Octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
- (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3R,4R,5R,13aR,13bS)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
- (3R,4S,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- (3S,4S,5S,13aS,13bS)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- 12-beta,13-beta-Dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine
- 14,19-Dihydro-12,13-dihydroxy(13-alpha,14-alpha)-20-norcrotalanan-11,15-dione
- 14,19-Dihydro-12,13-dihydroxy-20-norcrotolanan-11,15-dione
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)-
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)- (9CI)
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
- 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13α,14α)-
- 2H-(1,6)Dioxacycloundecino(2,3,4-gh)pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-
- 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine, 20-norcrotalanan-11,15-dione deriv.
- 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, [3R-(3R*,4R*,5R*,13aR*,13bR*)]-
- A 6080
- Brn 0048732
- Ccris 416
- Crotaline
- Hsdb 3513
- Monocrotalin
- Nci-C56462
- Nsc 28693
- Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate
- Monocrotaline
- 4-27-00-06660 (Beilstein Handbook Reference)
- 4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
- MONOCROTOLLINE (99%)
- Bulbus Lilii
- Monocrotoline
- CROTALIN
- (13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio
- Monocrotaline/crotaline
- Monocrotaline, >=98%
- MONOCRATALINE
- Monccrotalire
- (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,1
- Monocrotalinum
- 14,19-Dihydro-12,13-dihydroxy(13alpha,14alpha)-20-norcrotalanan-11,15-dione
- MONOCROTALIN(CROTALIN)(RG)
- 5-trimethyl-2h-(1,6)dioxacycloundecino-droxy-4
- 20-norcrotalanan-11,15-dione,14,19-dihydro-12,13-dihydroxy-,(13-alpha,14-al
- (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy
- Crotaline,Monocrotaline
- Monocrotaline,99%
- (13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione
- Weitere Synonyme anzeigen
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15 Produkte.
Monocrotalin
CAS:Monocrotalin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.Formel:C16H23NO6Reinheit:(HPLC) ≥90%Farbe und Form:PowderMolekulargewicht:325.37(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-Dione
CAS:(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-DioneReinheit:98%Molekulargewicht:325.36g/molCrotaline
CAS:Formel:C16H23NO6Reinheit:≥ 98.0%Farbe und Form:White to off-white crystalline powderMolekulargewicht:325.36Monocrotaline
CAS:<p>Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and has certain cellular activity against HepG2 cells.Cost-effective and quality-assured.</p>Formel:C16H23NO6Reinheit:98% - 99.94%Farbe und Form:White To Light Tan PowderMolekulargewicht:325.36Monocrotaline
CAS:Natural alkaloidFormel:C16H23NO6Reinheit:≥ 95.0 % (HPLC)Farbe und Form:PowderMolekulargewicht:325.36Monocrotaline
CAS:<p>Applications A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),<br></p>Formel:C16H23NO6Farbe und Form:White To Off-WhiteMolekulargewicht:325.36Monocrotaline
CAS:Toxin; induces pulmonary hypertensionFormel:C16H23NO6Reinheit:Min. 98%Farbe und Form:White Off-White Clear LiquidMolekulargewicht:325.36 g/molMonocrotaline-d4
CAS:Kontrolliertes Produkt<p>Applications Monocrotaline-d4 is labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),<br></p>Formel:C16D4H19NO6Farbe und Form:NeatMolekulargewicht:329.382
![(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxac…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1026386.jpg&w=3840&q=75)
