CAS 432531-71-0

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

CAS: 432531-71-0

Formel: C₁₈H₁₅N₅O₆S₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 461.4716

Ref: IN-DA00DF2R

(E/Z)-Necrosulfonamide

CAS: 432531-71-0

(E/Z)-Necrosulfonamide

Reinheit: ≥95%

Molekulargewicht: 461.47g/mol

Ref: 54-BUP09704

(E/Z)-Necrosulfonamide

CAS: 432531-71-0

(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

Formel: C₁₈H₁₅N₅O₆S₂

Reinheit: 97.62% - 98%

Farbe und Form: Solid

Molekulargewicht: 461.47

Ref: TM-T7129

Necrosulfonamide

Kontrolliertes Produkt

CAS: 432531-71-0

Applications Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
References Sun, L. et al.: Cell, 148, 213 (2012);

Formel: C₁₈H₁₅N₅O₆S₂

Farbe und Form: Neat

Molekulargewicht: 461.47

Ref: TR-N388600

MLKL Inhibitor, Necrosulfonamide

CAS: 432531-71-0

Necrosulfonamide is a chemical inhibitor of MLKL, a protein that is involved in apoptosis and necroptosis. Necrosulfonamide has been shown to inhibit the kinase activity of MLKL and induce cell death by apoptosis or necroptosis. It has also been shown to inhibit cancer cell growth and suppress tumor development in animal models. Necrosulfonamide binds to MLKL and prevents its interaction with other proteins, inhibiting mitochondrial functions and leading to necrosis or necroptosis. Necrosulfonamide has also shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

Formel: C₁₈H₁₅N₅O₆S₂

Reinheit: Min. 95%

Molekulargewicht: 461.47 g/mol

Ref: 3D-HSA53171