CAS 47931-85-1

Calcitonin (Lachs)

Beschreibung:

Calcitonin (Lachs) ist ein Peptidhormon, das eine entscheidende Rolle bei der Calciumhomöostase und dem Knochenstoffwechsel spielt. Es stammt von der Lachsart, die eine potentere Form im Vergleich zur menschlichen Calcitonin hat. Diese Substanz besteht aus 32 Aminosäuren und ist bekannt für ihre Fähigkeit, die Calciumspiegel im Blut zu senken, indem sie die Aktivität der Osteoklasten hemmt, was die Knochenresorption verringert. Calcitonin fördert auch die renale Ausscheidung von Calcium und Phosphat, was weiter zu seinen hypokalzämischen Effekten beiträgt. Es wird häufig in klinischen Einrichtungen zur Behandlung von Erkrankungen wie Osteoporose und Morbus Paget eingesetzt. Die CAS-Nummer 47931-85-1 identifiziert diese spezifische Formulierung von Calcitonin eindeutig. In Bezug auf die physikalischen Eigenschaften wird Calcitonin (Lachs) typischerweise durch Injektion verabreicht, da seine peptidische Natur seine Bioverfügbarkeit bei oraler Einnahme einschränkt. Seine therapeutischen Effekte sind in der Regel schnell, was es zu einer wertvollen Option bei der Behandlung von Hyperkalzämie und verwandten Störungen macht.

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

InChl: InChI=1/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)

SMILES: CC(C)CC(C(=NCC(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CO)C(=NC(CCC(=N)O)C(=NC(CCC(=O)O)C(=NC(CC(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(C(C)O)C(=NC(Cc1ccc(cc1)O)C(=O)N1CCCC1C(=NC(CCCNC(=N)N)C(=NC(C(C)O)C(=NC(CC(=N)O)C(=NC(C(C)O)C(=NCC(=NC(CO)C(=NCC(=NC(C(C)O)C(=O)N1CCCC1C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(C(C)C)N=C(C1CSSCC(C(=NC(CO)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NC(CO)C(=NC(C(C)O)C(=N1)O)O)O)O)O)O)N)O)O

Synonyme:

• Calcitonin (salmon I)
• Thyrocalcitonin Salmon
• H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond)
• Thyrocalcitonin
• Salmon calcitonin
• Salcitonin
• Salmon Calcitonin acetate
• Salmon
• Calcitonin salmon Acetate
• Calciben
• Calcimar
• Calcitonin (Lachs)
• Calcitonin (salmon reduced) cyclic (1→7)-disulfide
• Calcitonina (Salmon)
• Calcitonine (Saumon)
• Calsyn
• Calsynar
• Catonin
• Karil
• L-Prolinamide, L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-, cyclic (1→7)-disulfide
• Miacalcic
• Miacalcin
• Miadenil
• Prontocalcin
• Rulicalcin
• Salcatonin
• Salmon calcitonin I
• Salmon calcitonin-(1-32)
• Salmon Thyrocalcitonin
• Salmotonin
• Stalcin
• Tonocalcin
• Calcitonin(Salmone) Acetate

Calcitonin (salmon I)

CAS: 47931-85-1

Calcitonin inhibits osteoclast activity, lowers the blood calcium level, and positively influences bone mass density. Salmon calcitonin (sCT) is more potent than the human analog. sCT may act as an amylin agonist (Wielinga et al.). In animal studies, administration of sCT was shown to reduce food intake.

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Reinheit: 99.3%

Farbe und Form: White Lyophilisate

Molekulargewicht: 3431.9

Ref: 01-4033011

CALCITONIN-GLY CRS

CAS: 115472-96-3, 47931-85-1

CALCITONIN-GLY CRS

Ref: 41-Y0000632

CALCITONIN (SALMON) CRS

CAS: 47931-85-1

CALCITONIN (SALMON) CRS

Formel: C₈H₆BrN

Molekulargewicht: 196.0439

Ref: 41-C0200000

Calcitonin Salmon

CAS: 47931-85-1

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Farbe und Form: White Off-White Powder

Molekulargewicht: 3429.71331

Ref: 45-1086200

Calcitonin (Salmon)

CAS: 47931-85-1

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Molekulargewicht: 3431.90

Ref: 4Z-PC-322001

Calcitonin Salmon

CAS: 47931-85-1

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Reinheit: >95.0%(HPLC)

Farbe und Form: White to Almost white powder to crystal

Molekulargewicht: 3,431.90

Ref: 3B-C3597

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Reinheit: 99.41% - 99.80%

Farbe und Form: Powder

Molekulargewicht: 3431.85

Ref: TM-TP1040

Calcitonin Acetate(Salmon)

CAS: 47931-85-1

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Reinheit: 95%~99%

Farbe und Form: White to Off-white Powder

Molekulargewicht: 3431.85

Ref: BP-BPPG013

Calcitonin Salmon RS

CAS: 47931-85-1, 5989-81-1

Farbe und Form: White Solid

Ref: 2K-1039500021

Calcitonin, Salmon

CAS: 47931-85-1

Applications Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties.

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Farbe und Form: Neat

Molekulargewicht: 3431.85

Ref: TR-C144558

N-Acetyl-cys(1)-calcitonin Salmon Trifluoroacetic Acid Salt

Kontrolliertes Produkt

CAS: 47931-85-1

Applications N-Acetyl-cys(1)-calcitonin Salmon is a derivative of Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF., et al.: Med. Physi., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Formel: C₁₄₇H₂₄₃N₄₄O₄₉S₂·x(C₂HF₃O₂)

Farbe und Form: Neat

Molekulargewicht: 3475.5911402

Ref: TR-A168465

Calcitonin (salmon) xAcetate

Kontrolliertes Produkt

CAS: 47931-85-1

Applications Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF. et al.: Med. Phys., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂·x(CH₃CO₂H)

Farbe und Form: Neat

Molekulargewicht: 3431.856005

Ref: TR-C144555

Calcitonin

CAS: 47931-85-1

Calcitonin is a peptide hormone that inhibits the release of calcium from bone, and decreases the blood level of calcium. Calcitonin is not active in the absence of parathyroid hormone (PTH) or vitamin D. It has been shown to inhibit the development of experimental myocardial infarcts in rats by inhibiting the release of calcium from bone, and has also been shown to have a protective effect on brain function. The calcitonin receptor is activated by binding with calcitonin, which then activates adenylyl cyclase and increases intracellular cAMP levels. This leads to increased activity at ATP-sensitive potassium channels, which causes hyperpolarisation of neurons. Caudate putamen neurons are particularly sensitive to calcitonin activity because they are rich in voltage-gated K+ channels that are sensitive to ATP-sensitive potassium channel activation. Calcitonin also plays a role in regulating serum Ca2+ concentration by inhib

Formel: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Reinheit: Min. 95%

Molekulargewicht: 3,431.86 g/mol

Ref: 3D-FC36651

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon)

Farbe und Form: White Powder

Ref: 47-355