CAS 484-42-4

Angiotensin I

Beschreibung:

Angiotensin I ist ein Peptidhormon, das eine entscheidende Rolle bei der Regulierung des Blutdrucks und des Flüssigkeitsgleichgewichts im Körper spielt. Es ist ein Dekapeptid, das aus zehn Aminosäuren besteht und aus Angiotensinogen, einem Vorläuferprotein, das von der Leber produziert wird, abgeleitet ist. Angiotensin I ist biologisch inaktiv, wird jedoch durch die Wirkung des Enzyms Angiotensin-Converting-Enzym (ACE) in die aktive Form Angiotensin II umgewandelt. Diese Umwandlung ist ein entscheidender Schritt im Renin-Angiotensin-System, das den Blutdruck und das Elektrolytgleichgewicht reguliert. Angiotensin I zeichnet sich durch seine spezifische Aminosäuresequenz aus, die Prolin- und Histidinreste umfasst und zu seinen strukturellen Eigenschaften beiträgt. Es ist in Wasser löslich und hat eine relativ kurze Halbwertszeit im Blutkreislauf, was es zu einem transienten Bestandteil des Renin-Angiotensin-Systems macht. Die Untersuchung von Angiotensin I und seinen Derivaten ist in der Pharmakologie von Bedeutung, insbesondere bei der Entwicklung von blutdrucksenkenden Medikamenten, die auf das Renin-Angiotensin-System abzielen, um Erkrankungen wie Bluthochdruck und Herzinsuffizienz zu behandeln.

Formel: C₆₂H₈₉N₁₇O₁₄

InChl: InChI=1/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](CC(C)C)C(=O)O)O)O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](C(C)C)N=C([C@H](CCCNC(=N)N)N=C([C@H](CC(=O)O)N)O)O)O)O

Synonyme:

• H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH
• L-alpha-aspartyl-N~5~-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine

Angiotensin I (human)

CAS: 484-42-4

Angiotensin I (human) stimulates the release of aldosterone, another hormone, from the adrenal cortex. It acts as a precursor to angiotensin II. It acts as endogenous peptide substrate for angiotensin converting enzyme (ACE), precursor to the vasoconstrictor peptide angiotensin II This Thermo Scient

Formel: C₆₂H₈₉N₁₇O₁₄

Farbe und Form: White, Powder

Molekulargewicht: 1296.50

Ref: 02-J62102

Angiotensin I

CAS: 484-42-4

Angiotensin I, DRVYIHPFHL, is cleaved by angiotensin-converting enzyme (ACE) yielding Ang II and the dipeptide His-Leu. Ang I is also converted to Ang II by chymase, especially in the human heart. Hence, this mast cell protease is also involved in blood pressure regulation. The chymase pathway gains importance in inflammatory conditions.

Formel: C₆₂H₈₉N₁₇O₁₄

Reinheit: 97.9%

Farbe und Form: White

Molekulargewicht: 1296.5

Ref: 01-4002346

Angiotensin 1, Human

CAS: 484-42-4

Formel: C₆₂H₈₉N₁₇O₁₄

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 1296.4756

Ref: IN-DA00DEOP

Angiotensin I (human, mouse, rat)

CAS: 484-42-4

Angiotensin I (human, mouse, rat)

Reinheit: ≥98%

Molekulargewicht: 1296.48g/mol

Ref: 54-BUP21214

Angiotensin I (human, mouse, rat)

CAS: 484-42-4

Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).

Formel: C₆₂H₈₉N₁₇O₁₄

Reinheit: >99.99%

Farbe und Form: Solid

Molekulargewicht: 1296.48

Ref: TM-TP1295

Angiotensin I

CAS: 484-42-4

The renin angiotensin system (RAS), consists of many angiotensin peptides involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and RAS is widely studied in relation to lifestyle-related diseases.Angiotensin I (Ang-I), is the first angiotensin to be produced upon activation of the RAS system. It is produced by the cleavage of angiotensinogen (AGT), catalysed by the aspartylprotease, renin. The dicarboxyl-peptidase angiotensin converting enzyme (ACE), then removes two amino acids from the C-terminus of Ang-I to form angiotensin II (Ang-II), and His-Leu.Ang-I is also converted to Ang-II by chymase, especially in the human heart. The chymase pathway is important in inflammatory conditions.

Formel: C₆₂H₈₉N₁₇O₁₄

Molekulargewicht: 1,296.48 g/mol

Ref: 3D-CRB1000132

Angiotensin I, human

CAS: 484-42-4

Angiotensin I is a protein encoded by the AGTR1 gene. It is a precursor to angiotensin II, which causes vasoconstriction and has other effects on blood vessels, kidneys, and the heart. Angiotensin I is produced by proteolytic cleavage of pro-angiotensinogen in the liver. The mouse monoclonal antibody to human angiotensin I (mAb-HAI) recognizes both human and bovine angiotensin I. This antibody can be used for immunohistochemistry or Western blot analysis of cells from mice that have been injected with mAb-HAI. It has also been shown to reduce kidney fibrosis in mice when it is administered as a subcutaneous injection three times per week.

Formel: C₆₂H₈₉N₁₇O₁₄

Reinheit: Min. 95%

Molekulargewicht: 1,296.48 g/mol

Ref: 3D-FA73185

Angiotensin I (Human)

CAS: 484-42-4

Angiotensin I (Human) is a peptide that functions as a hormone. It is the major regulator of blood pressure and plays an important role in the regulation of fluid balance, electrolyte balance, and heart rate. Angiotensin I (Human) is a receptor ligand that binds to cell surface receptors which are coupled to G proteins. It has been used extensively as a research tool for studying protein interactions and ion channels.

Formel: C₆₂H₈₉N₁₇O₁₄

Reinheit: Min. 95%

Molekulargewicht: 1,296.5 g/mol

Ref: 3D-PAN-4007-V

Angiotensin I (Human)

CAS: 484-42-4

Angiotensin I (Human) is a protein that is found in the blood and other tissues. It is a peptide hormone, which acts on the kidneys to increase blood pressure and on the heart to increase cardiac output. This protein has been detected in several biological samples such as plasma, serum, or urine. Angiotensin I (Human) can be used as an enzyme form of angiotensin 1-converting enzyme (ACE). ACE catalyzes the conversion of angiotensin I to its active form, angiotensin II. Angiotensin II has been shown to reduce the production of inflammatory cytokines such as tumor necrosis factor-alpha and interleukins. It also stimulates vascular smooth muscle cells and increases the production of nitric oxide by these cells, leading to vasodilation. The measurement of this enzyme form in a sample may help determine disease activity in patients with bowel disease or squamous cell cancer of the skin.

Formel: C₆₂H₈₉N₁₇O₁₄•2CH₃COOH•4H₂O

Reinheit: Min. 95%

Molekulargewicht: 1,488.66 g/mol

Ref: 3D-PAN-4007

Angiotensin I, human

CAS: 484-42-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formel: C₆₂H₈₉N₁₇O₁₄

Molekulargewicht: 1,296.5 g/mol

Ref: 3D-PP50338