CAS 51833-78-4

Angiotensin-Fragment 1-7 menschliches Acetat

Beschreibung:

Das Angiotensinfragment 1-7, auch bekannt als Angiotensin 1-7 oder A-1-7, ist ein Peptid, das eine entscheidende Rolle im Renin-Angiotensin-System spielt, das den Blutdruck und das Flüssigkeitsgleichgewicht reguliert. Dieses Fragment stammt von der Spaltung von Angiotensin II und ist bekannt für seine vasodilatierenden Effekte, die die kardiovaskuläre Gesundheit fördern, indem sie die Wirkungen von Angiotensin II entgegenwirken. Die Acetatform zeigt an, dass das Peptid in einer Salzform vorliegt, was seine Stabilität und Löslichkeit verbessern kann. Charakteristisch zeigt Angiotensin 1-7 biologische Aktivität durch seine Wechselwirkung mit dem Mas-Rezeptor, was zu verschiedenen physiologischen Effekten führt, einschließlich entzündungshemmender und antifibrotischer Wirkungen. Es wird häufig auf seine potenziellen therapeutischen Anwendungen bei Erkrankungen wie Bluthochdruck, Herzinsuffizienz und Nierenerkrankungen untersucht. Die CAS-Nummer 51833-78-4 identifiziert dieses spezifische Peptid eindeutig und erleichtert dessen Erkennung in der wissenschaftlichen Literatur und in Datenbanken. Insgesamt ist das Angiotensinfragment 1-7 ein bedeutendes Biomolekül mit Implikationen in der kardiovaskulären Physiologie und potenziellen klinischen Anwendungen.

Formel: C₄₁H₆₂N₁₂O₁₁

InChl: InChI=1/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](C(C)C)N=C([C@H](CCCNC(=N)N)N=C([C@H](CC(=O)O)N)O)O)O)O

Synonyme:

• Angiotensin I/II (1-7)
• H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH
• L-alpha-aspartyl-N~5~-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline

Angiotensin I/II (1-7)

CAS: 51833-78-4

Angiotensin (1-7), DRVYIHP, an enzymatically produced peptide of the renin-angiotensin system, shows pharmacologically distinct, tissue-specific actions that differ from those of angiotensin II. Angiotensin (1-7) shows considerable cardiovascular and antiangiogenic activity. Iusuf et al. reviewed its phamacological properties and pharmacotherapeutic perspectives. Moreover, the heptapeptide was shown to inhibit the growth of human lung cancer cells in vitro and to reduce the size of human lung cancer xenografts in vivo.

Formel: C₄₁H₆₂N₁₂O₁₁

Reinheit: 99.3%

Farbe und Form: White Powder

Molekulargewicht: 899.02

Ref: 01-4006081

ASP-ARG-VAL-TYR-ILE-HIS-PRO

CAS: 51833-78-4

Formel: C₄₁H₆₂N₁₂O₁₁

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 899.0048

Ref: IN-DA00D884

Angiotensin (1-7)

CAS: 51833-78-4

Angiotensin (1-7)

Reinheit: ≥98%

Molekulargewicht: 899g/mol

Ref: 54-BUP02118

Angiotensin (1-7) acetate salt hydrate

CAS: 51833-78-4

Molekulargewicht: 899.00 (anhydrous)

Ref: 7W-GM0621

Angiotensin I (1-7)

CAS: 51833-78-4

Formel: C₄₁H₆₂N₁₂O₁₁

Molekulargewicht: 899.02

Ref: 4Z-A-258001

Angiotensin (1-7)

CAS: 51833-78-4

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide, inhibits canine ACE activity with vasodilator and antiproliferative activities.

Formel: C₄₁H₆₂N₁₂O₁₁

Reinheit: >99.99%

Farbe und Form: White Lyophilised Solid

Molekulargewicht: 899

Ref: TM-T7339

Angiotensin, Canine, Rat

CAS: 51833-78-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formel: C₄₁H₆₂N₁₂O₁₁

Molekulargewicht: 899 g/mol

Ref: 3D-PP50386

Angiotensin (Human, 1-7)

CAS: 51833-78-4

Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang-(1-7) directly from angiotensin I (Ang-I).Ang-(1-7) broadly opposes Ang-II actions. Ang-(1-7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang-(1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.

Formel: C₄₁H₆₂N₁₂O₁₁

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 899.01 g/mol

Ref: 3D-CRB1000803

Angiotensin (1-7) xTFA salt

Kontrolliertes Produkt

CAS: 51833-78-4

Applications Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.
References Verlackt, C., et al.: J Phys Chem C, 121, 5787 (2017)

Formel: C₄₁H₆₂N₁₂O₁₁·xTFA

Farbe und Form: Neat

Molekulargewicht: 899.00 + x(114.02)

Ref: TR-A637945

Angiotensin (Human, 1-7)

CAS: 51833-78-4

Angiotensin (Human, 1-7) is a peptide hormone that is produced in the body by the renin-angiotensin system. This peptide hormone helps to regulate blood pressure and blood volume. Angiotensin (Human, 1-7) works by activating both receptors on cells, which causes vasoconstriction and stimulates the release of aldosterone from the adrenal gland. Angiotensin (Human, 1-7) can also stimulate various ion channels and cause vasoconstriction. The antibody against this peptide may be used as a research tool for studying its function in cell biology or as an inhibitor or activator in pharmacology.

Formel: C₄₁H₆₂N₁₂O₁₁•CH₃COOH•4H₂O

Reinheit: Min. 95%

Molekulargewicht: 1,031.11 g/mol

Ref: 3D-PAN-4332

Angiotensin (Human, 1-7)

CAS: 51833-78-4

Angiotensin (human, 1-7) is a peptide that acts as an agonist for the angiotensin II receptor. It is used in research as a pharmacological tool and in cell biology to study protein interactions and signaling pathways. It is also used to study the role of angiotensin receptors in various diseases such as hypertension and heart disease. Angiotensin (human, 1-7) is supplied at high purity and without any contaminants.

Formel: C₄₁H₆₂N₁₂O₁₁

Reinheit: Min. 95%

Molekulargewicht: 899 g/mol

Ref: 3D-PAN-4332-V

Angiotensin I/II (1-7) trifluoroacetate salt

CAS: 51833-78-4

Angiotensin I/II (1-7) trifluoroacetate salt is a selective inhibitor of angiotensin II. It blocks the activity of angiotensin II, and thereby prevents the activation of growth factor-β1, which leads to a decrease in pulmonary hypertension. The drug has also been shown to be effective in blocking dextran sulfate absorption, as well as preventing bowel disease by inhibiting receptor activity. Angiotensin I/II (1-7) trifluoroacetate salt has been shown to have an anti-inflammatory effect on the cardiovascular system by blocking cell signaling pathways and reducing blood pressure. This drug is used for treatment of metabolic disorders such as atherosclerotic lesion, cardiac diseases such as coronary heart diseases, and bowel disease.

Formel: C₄₁H₆₂N₁₂O₁₁

Reinheit: Min. 95%

Molekulargewicht: 899.01 g/mol

Ref: 3D-FA108515