CAS 52232-67-4

Teriparatid

Beschreibung:

Teriparatid ist eine synthetische Form des Parathormons (PTH), die hauptsächlich zur Behandlung von Osteoporose eingesetzt wird. Es zeichnet sich durch seine Fähigkeit aus, die Knochenbildung zu stimulieren, was es von anderen Osteoporosebehandlungen unterscheidet, die sich hauptsächlich auf die Hemmung der Knochenresorption konzentrieren. Teriparatid wird durch subkutane Injektion verabreicht und wird typischerweise für Patienten mit hohem Frakturrisiko verschrieben. Die Substanz besteht aus den ersten 34 Aminosäuren des menschlichen PTH, die für ihre biologische Aktivität entscheidend sind. Ihr Wirkmechanismus besteht darin, an PTH-Rezeptoren auf Osteoblasten zu binden, das Knochenwachstum zu fördern und die Calciumaufnahme im Darm und in den Nieren zu erhöhen. Teriparatid hat eine relativ kurze Halbwertszeit, was eine tägliche Verabreichung für optimale therapeutische Effekte erforderlich macht. Zu den häufigen Nebenwirkungen können Übelkeit, Schwindel und Wadenkrämpfe gehören. Aufgrund seiner anabolen Wirkung auf den Knochen wird Teriparatid häufig für den Einsatz bei postmenopausalen Frauen und Männern mit Osteoporose in Betracht gezogen, die eine Vorgeschichte von Frakturen oder signifikantem Knochenverlust haben.

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂・C₂H₄O<

InChl: InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)

SMILES: CCC(C)C(C(=NC(CCC(=N)O)C(=NC(CC(C)C)C(=NC(CCSC)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NCC(=NC(CCCCN)C(=NC(Cc1cnc[nH]1)C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(CO)C(=NC(CCSC)C(=NC(CCC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(C(C)C)C(=NC(CCC(=O)O)C(=NC(Cc1c[nH]c2ccccc12)C(=NC(CC(C)C)C(=NC(CCCNC(=N)N)C(=NC(CCCCN)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(CC(=O)O)C(=NC(C(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(Cc1ccccc1)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CO)N=C(C(C(C)C)N=C(C(CO)N)O)O)O)O

Synonyme:

• Teriparatide Acetate
• Forteo
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt) hydrate
• L-Seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-phenylalanine acetate (salt) hydrate
• Parathar
• Parathar acetate
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt)

Parathyroid Hormone (1-34), human

CAS: 52232-67-4

Parathyroid Hormone (1-34), human

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Molekulargewicht: 4117.7

Ref: 02-J66180

pTH (1-34) (human)

CAS: 52232-67-4

Teriparatide, which consists of the N-terminal 34 amino acid residues of parathyroid hormone, shows the same potency and pharmacological profile as the native hormone. Administration of teriparatide stimulates bone formation and increases the bone mineral density (BMD).

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Reinheit: 99.1%

Farbe und Form: White

Molekulargewicht: 4117.77

Ref: 01-4011474

pTH (1-34) (human)

CAS: 52232-67-4

Intermittent administration of teriparatide stimulates bone formation by increasing the number of osteoblasts. Agonist of the parathyroid hormone receptor PTH1.

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Reinheit: 96.3%

Farbe und Form: White

Molekulargewicht: 4117.77

Ref: 01-4095855

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

CAS: 52232-67-4

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

Formel: C₁₃H₁₄ClNO

Molekulargewicht: 235.7094

Ref: 41-Y0001895

TERIPARATIDE CRS

CAS: 52232-67-4

TERIPARATIDE CRS

Formel: C₁₃H₁₄ClNO

Farbe und Form: Added Added

Molekulargewicht: 235.7094

Ref: 41-Y0001916

Teriparatide

CAS: 52232-67-4

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Farbe und Form: White Off-White Powder

Molekulargewicht: 4115.13094

Ref: 45-1643962

Teriparatide acetate

CAS: 52232-67-4

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Reinheit: 99%

Farbe und Form: Solid

Molekulargewicht: 4117.7151

Ref: IN-DA01CC00

Teriparatide Tetraacetate

CAS: 52232-67-4

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂·4C₂H₄O₂

Molekulargewicht: 4117.77 4*60.05

Ref: 4Z-PT-255001

Teriparatide

CAS: 52232-67-4

Teriparatide is an agonist of PHT(IC50 of 2 nM in HEK293 cells).

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 4117.72

Ref: TM-T13128

Teriparatide acetate

CAS: 52232-67-4

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Molekulargewicht: 4117.77

Ref: 7W-GX8046

pTH (1-34) (human)

CAS: 52232-67-4

pTH (1-34) (human)

Farbe und Form: Solid

Ref: 54-BIBA1023

Parathyroid Hormone Fragment (1-34)- 24,d3 TFA Salt

Kontrolliertes Produkt

CAS: 52232-67-4

Stability Hygroscopic
Applications Parathyroid Hormone Fragment (1-34)-24,d3,TFA Salt is the labeled (on Leucine-d3, position 24) analogue of Parathyroid Hormone Fragment (1-34) (P192200), which is a fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Formel: C₁₈₁D₃H₂₈₈N₅₅O₅₁S₂·xC₂O₂HF₃

Farbe und Form: Neat

Molekulargewicht: 4234.8

Ref: TR-P192202

Teriparatide-d10

Kontrolliertes Produkt

CAS: 52232-67-4

Formel: C₁₈₁D₁₀H₂₈₁N₅₅O₅₁S₂

Farbe und Form: Neat

Molekulargewicht: 4127.72

Ref: TR-T512227

Parathyroid Hormone Fragment (1-34)

Kontrolliertes Produkt

CAS: 52232-67-4

Applications A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Farbe und Form: Neat

Molekulargewicht: 4117.72

Ref: TR-P192200

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.5mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is possible that in can be used in research in the treatments of some types of osteoporosis. PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Reinheit: Min. 95%

Molekulargewicht: 4,117.7 g/mol

Ref: 3D-PTH-4068-V

TeripaRatide Acetate

CAS: 52232-67-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Molekulargewicht: 4,117.8 g/mol

Ref: 3D-PP50195

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.1mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is also an effective anabolic agent used in the treatment of some forms of Osteoporosis. PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Formel: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Reinheit: Min. 95%

Molekulargewicht: 4,117.7 g/mol

Ref: 3D-PTH-4068-S