CAS 53-86-1
:Indometacin
Beschreibung:
Indometacin ist ein nichtsteroidales entzündungshemmendes Medikament (NSAID), das hauptsächlich zur Linderung von Schmerzen, Schwellungen und Entzündungen eingesetzt wird, die mit verschiedenen Erkrankungen wie Arthritis und Gicht verbunden sind. Es wird als Derivat der Indolessigsäure klassifiziert und weist starke entzündungshemmende und schmerzlindernde Eigenschaften auf. Die chemische Formel von Indometacin lautet C19H16ClN und hat ein Molekulargewicht von etwa 357,79 g/mol. Indometacin wirkt, indem es die Cyclooxygenase (COX)-Enzyme hemmt, die eine entscheidende Rolle bei der Synthese von Prostaglandinen, Mediatoren von Entzündungen und Schmerzen, spielen. Die Substanz wird typischerweise oral verabreicht, kann aber auch rektal oder intravenös verabreicht werden. Indometacin ist bekannt für seine potenziellen Nebenwirkungen, die gastrointestinale Probleme, kardiovaskuläre Risiken und Nierenbeeinträchtigungen umfassen können, was eine sorgfältige Überwachung während der Anwendung erforderlich macht. Seine Löslichkeit ist in Wasser moderat, aber es ist in organischen Lösungsmitteln besser löslich, was seine Formulierung in pharmazeutischen Zubereitungen beeinflusst. Insgesamt bleibt Indometacin ein wichtiges Therapeutikum zur Behandlung entzündlicher Erkrankungen.
Formel:C19H16ClNO4
InChl:InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI Key:InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Synonyme:- 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
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- Nsc 77541
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- Rheumacin LA
- Sadoreum
- Tannex
- Vital Vitacid
- Vonum
- [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate
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Indomethacin
CAS:Formel:C19H16ClNO4Reinheit:>98.0%(T)(HPLC)Farbe und Form:White to Light yellow to Light orange powder to crystalMolekulargewicht:357.79Indomethacin, 98%
CAS:<p>It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also p</p>Formel:C19H16ClNO4Reinheit:98%Farbe und Form:White to pale cream, PowderMolekulargewicht:357.79Indomethacin, 99+%
CAS:<p>Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.</p>Formel:C19H16ClNO4Reinheit:99+%Molekulargewicht:357.8INDOMETACIN IMPURITY MIXTURE CRS
CAS:INDOMETACIN IMPURITY MIXTURE CRSFormel:C17H19N3Molekulargewicht:265.3529INDOMETACIN CRS
CAS:INDOMETACIN CRSFormel:C17H19N3Farbe und Form:Crystalline Powder. White. Yellow. Powder.Molekulargewicht:265.3529Indomethacin
CAS:Analgesics, antipyretics and non-hormonal anti-inflammatory agentsFormel:C19H16ClNO4Farbe und Form:White Yellow PowderMolekulargewicht:357.79Indomethacin
CAS:Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.Formel:C19H16ClNO4Reinheit:99.27% - 99.76%Farbe und Form:Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)Molekulargewicht:357.79Indomethacin
CAS:Formel:C19H16ClNO4Reinheit:≥ 98.0% (dried basis)Farbe und Form:White to off-white or pale pink powderMolekulargewicht:357.80Indomethacin, BP grade
CAS:Formel:C19H16ClNO4Reinheit:(Titration) 98.5 - 100.5 % (dried basis)Farbe und Form:White to yellow powder or crystalsMolekulargewicht:357.80Indomethacin (Indometacin) EP Impurity D
CAS:Formel:C19H16ClNO4Farbe und Form:White To Off-White SolidMolekulargewicht:357.79Indomethacin
CAS:Kontrolliertes Produkt<p>Impurity Acemetacin EP Impurity B<br>Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Formel:C19H16ClNO4Farbe und Form:BeigeMolekulargewicht:357.79Indomethacin
CAS:<p>Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.</p>Formel:C19H16ClNO4Reinheit:Min. 95%Farbe und Form:White PowderMolekulargewicht:357.79 g/molIndomethacin - Bio-X ™
CAS:<p>Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formel:C19H16ClNO4Reinheit:(%) Min. 95%Farbe und Form:PowderMolekulargewicht:357.79 g/mol
