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CAS 53123-88-9

:

Rapamycin

Beschreibung:
Rapamycin, auch bekannt als Sirolimus, ist eine Makrolidverbindung mit der CAS-Nummer 53123-88-9. Es wird von dem Bakterium *Streptomyces hygroscopicus* produziert und ist hauptsächlich für seine immunsuppressiven Eigenschaften bekannt, was es wertvoll für die Organtransplantation zur Verhinderung von Abstoßung macht. Rapamycin wirkt, indem es das mammalische Ziel von Rapamycin (mTOR) hemmt, einen Schlüsselregulator für Zellwachstum, Proliferation und Überleben. Diese Hemmung führt zu einer Verringerung der Aktivierung und Proliferation von T-Zellen. Neben seinen immunsuppressiven Effekten hat Rapamycin auch Aufmerksamkeit für seine potenziellen antitumoralen Eigenschaften und seine Rolle bei der Förderung der Langlebigkeit in verschiedenen Modellorganismen erregt. Die Verbindung wird typischerweise oral verabreicht und hat eine relativ lange Halbwertszeit, die nachhaltige therapeutische Effekte ermöglicht. Es kann jedoch Nebenwirkungen haben, einschließlich eines erhöhten Infektionsrisikos, metabolischer Störungen und potenzieller Lungentoxizität. Aufgrund seiner komplexen Pharmakokinetik ist oft eine Überwachung der Blutspiegel erforderlich, um die Dosierung zu optimieren und unerwünschte Wirkungen zu minimieren.
Formel:C51H79NO13
InChl:InChI=1/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12-,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38?,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI Key:InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N
SMILES:O=C1N2[C@](C(=O)O[C@]([C@@H](C[C@H]3C[C@@H](OC)[C@H](O)CC3)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@@H](OC)C[C@]4(O[C@@](O)(C1=O)[C@H](C)CC4)[H])[H])(CCCC2)[H]
Synonyme:
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • 14S-Rapamycin
  • 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*S*1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, [3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-
  • 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • Antibiotic AY 22989
  • Weitere Synonyme anzeigen
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18 Produkte.
  • Rapamycin, 98+%

    CAS:
    <p>Rapamycin, 53123-88-9, also known as Sirolimus, is a macrolide which exhibits antitumor and immunosuppressive activity. Learn more at Thermo Fisher Scientific.</p>
    Formel:C51H79NO13
    Reinheit:98+%
    Farbe und Form:White to cream to yellow, Powder or crystals or crystalline powder
    Molekulargewicht:914.19

    Ref: 02-J62473

    50mg
    Nachfragen
    100mg
    237,00€
    200mg
    295,00€
  • Rapamycin

    CAS:
    <p>M02444 - Rapamycin</p>
    Formel:C51H79NO13
    Reinheit:98%
    Farbe und Form:Solid, Crystalline Powder or Granules or Powder
    Molekulargewicht:914.187

    Ref: 10-M02444

    1g
    102,00€
    5g
    408,00€
    10mg
    24,00€
    50mg
    31,00€
    100mg
    34,00€
    250mg
    96,00€
    500mg
    91,00€
  • Sirolimus

    CAS:
    Antibiotics nesoi
    Formel:C51H79NO13
    Farbe und Form:Off-White White Powder
    Molekulargewicht:913.55514
  • Rapamycin

    CAS:
    <p>Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.</p>
    Formel:C51H79NO13
    Reinheit:97.08% - 99.80%
    Farbe und Form:Yellow Solid
    Molekulargewicht:914.17
  • Ref: IN-DA0035KC

    1g
    111,00€
    5g
    284,00€
    10g
    518,00€
    25g
    Nachfragen
    50mg
    28,00€
    100mg
    34,00€
    250mg
    53,00€
    500mg
    69,00€
  • Rapamycin

    CAS:
    Rapamycin
    Reinheit:≥95%
    Molekulargewicht:914.17g/mol

    Ref: 54-BUP17166

    10mg
    53,00€
    25mg
    64,00€
    50mg
    76,00€
    100mg
    96,00€
    200mg
    163,00€
    500mg
    273,00€
  • Rapamycin (Sirolimus)

    CAS:
    Formel:C51H79NO13
    Farbe und Form:White To Off-White Solid
    Molekulargewicht:914.19

    Ref: 4Z-R-182

    5mg
    Nachfragen
    10mg
    349,00€
    25mg
    444,00€
    50mg
    635,00€
    100mg
    Nachfragen
  • Rapamycin

    CAS:
    Formel:C51H79NO13
    Reinheit:98.0 - 102.0 % (anhydrous basis)
    Farbe und Form:White to yellow crystalline powder
    Molekulargewicht:914.17

    Ref: 7W-GA7417

    5mg
    33,00€
    25mg
    79,00€
    50mg
    148,00€
    100mg
    243,00€
  • Rapamycin from Streptomyces hygroscopicus

    CAS:
    Rapamycin from Streptomyces hygroscopicus
    Formel:C51H79NO13
    Reinheit:By hplc: 99.14% (Typical Value in Batch COA)
    Farbe und Form: white powder
    Molekulargewicht:914.17186g/mol

    Ref: 54-BIR8101

    1g
    210,00€
    5g
    712,00€
    500mg
    128,00€
  • Rapamycin

    CAS:
    Formel:C51H79NO13
    Reinheit:>98.0%(HPLC)
    Farbe und Form:White to Almost white powder to crystal
    Molekulargewicht:914.19

    Ref: 3B-R0097

    25mg
    83,00€
  • Rapamycin

    CAS:
    Formel:C51H79NO13
    Reinheit:95%~99%
    Molekulargewicht:914.187

    Ref: BP-BP1196

    ne
    Nachfragen
  • Rapamycin (>85%)

    CAS:
    <p>Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's.<br>References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),<br></p>
    Formel:C51H79NO13
    Reinheit:>85%
    Farbe und Form:Neat
    Molekulargewicht:914.17

    Ref: TR-R124000

    5mg
    112,00€
    50mg
    437,00€
    100mg
    768,00€
  • Everolimus EP Impurity A

    CAS:
    Formel:C51H79NO13
    Molekulargewicht:914.2

    Ref: ST-EA-CP-E33001

    10mg
    Nachfragen
    25mg
    Nachfragen
    50mg
    Nachfragen
    100mg
    Nachfragen
  • Rapamycin-13C,d3 (contains d0) Technical Grade

    Kontrolliertes Produkt
    CAS:
    <p>Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0.<br>References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),<br></p>
    Formel:C50CH76D3NO13
    Farbe und Form:Neat
    Molekulargewicht:918.18

    Ref: TR-R124003

    1mg
    617,00€
    5mg
    2.407,00€
    10mg
    4.429,00€
  • Rapamycin

    CAS:
    <p>Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.</p>
    Formel:C51H79NO13
    Reinheit:Min. 95 Area-%
    Farbe und Form:White Powder
    Molekulargewicht:914.17 g/mol

    Ref: 3D-AE27685

    1g
    696,00€
    2g
    944,00€
    5g
    1.780,00€
    250mg
    356,00€
    500mg
    506,00€
  • Rapamycin - Bio-X ™

    CAS:
    <p>Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.</p>
    Formel:C51H79NO13
    Reinheit:Min. 95%
    Farbe und Form:Powder
    Molekulargewicht:914.17 g/mol

    Ref: 3D-BR164324

    10mg
    135,00€
  • Rapamycin-13C,d3 (contains d0) - Technical Grade

    Kontrolliertes Produkt
    CAS:
    <p>Binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. Induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.</p>
    Formel:C50CH76D3NO13
    Reinheit:Min. 95%
    Molekulargewicht:918.18 g/mol

    Ref: 3D-BR177694

    1mg
    1.030,00€
    2mg
    1.627,00€
    5mg
    3.510,00€
  • Sirolimus

    CAS:
    Farbe und Form:Neat

    Ref: 04-CA16970700

    Ausgelaufenes produkt