CAS 54-42-2

5-Iodo-2'-desoxyuridin

Beschreibung:

5-Iodo-2'-desoxyuridin (IDU) ist ein Nukleosidanalogon der Thymidin, das durch das Vorhandensein eines Iodatoms an der 5-Position des Pyrimidinrings gekennzeichnet ist. Es wird hauptsächlich in der antiviralen Forschung und als potenzielles Therapeutikum in der Krebsbehandlung eingesetzt, da es die Fähigkeit hat, die DNA-Synthese zu stören. IDU ist ein weißes bis off-white kristallines Pulver, das in Wasser löslich ist und ein moderates Stabilitätsprofil unter physiologischen Bedingungen aufweist. Seine chemische Formel ist C₁₃H₁₂I N₃O₅, und es hat ein Molekulargewicht, das seine komplexe Struktur widerspiegelt. Die Verbindung ist bekannt dafür, die virale Replikation zu hemmen, insbesondere im Kontext des Herpes-simplex-Virus, und wird auch hinsichtlich ihrer Auswirkungen auf zelluläre Prozesse untersucht. IDU kann während der Replikation in die DNA eingebaut werden, was zu Mutationen und letztendlich zum Zelltod führt, ein Mechanismus, der in der Krebstherapie ausgenutzt wird. Sicherheits- und Handhabungsvorkehrungen sind aufgrund seiner potenziellen biologischen Wirkungen erforderlich, und es sollte in kontrollierten Laborumgebungen verwendet werden.

Formel: C₉H₁₁IN₂O₅

InChl: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI Key: InChIKey=XQFRJNBWHJMXHO-RRKCRQDMSA-N

SMILES: O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(I)C(=O)N1

Synonyme:

• 1-(2-Dehydroxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-iodouracil
• 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil
• 1-(2-deoxy-beta-D-threo-pentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-(2-deoxypentofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione
• 1-[(3xi)-2-deoxy-beta-D-glycero-pentofuranosyl]-5-iodopyrimidine-2,4(1H,3H)-dione
• 2'-Desoxy-5-iodouridine
• 2-Deoxy-5-iodouridine
• 5-Iodo-2'-Deoxy-D-Uridine
• 5-Iodo-2'-desoxyuridine
• 5-Iodo-deoxyuridine
• 5-Iododeoxyuridine
• 5-Iodouracil deoxyriboside
• 5Iudr
• Allergan 211
• Dendrid
• Emanil
• Herpe-Gel
• Herpesil
• Herpidu
• Herplex
• IDU
• Idexur
• Idoxene
• Idoxuridin
• Idoxuridina
• Idoxuridine
• Idu Oculos
• Iducher
• Idulea
• Idur
• Iduridin
• Iododeoxyuridine
• Iudr
• Joddeoxiuridin
• Kerecid
• Nsc 39661
• Ophthalmadine
• Skf 14287
• Stoxil
• Stoxip
• Synmiol
• Uridine, 2'-deoxy-5-iodo-
• Virudox

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Formel: C₉H₁₁IN₂O₅

Reinheit: >99.0%(T)

Farbe und Form: White to Almost white powder to crystal

Molekulargewicht: 354.10

Ref: 3B-I0258

(+)-5-Iodo-2'-deoxyuridine, 98%

CAS: 54-42-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formel: C₉H₁₁IN₂O₅

Reinheit: 98%

Farbe und Form: White to pale cream, Crystals or powder or crystalline powder

Molekulargewicht: 354.10

Ref: 02-A11542

IDOXURIDINE CRS

CAS: 54-42-2

IDOXURIDINE CRS

Formel: C₉H₁₁IN₂O₅

Farbe und Form: Powder

Molekulargewicht: 354.0985

Ref: 41-I0050000

Idoxuridine

CAS: 54-42-2

Idoxuridine

Formel: C₉H₁₁IN₂O₅

Reinheit: 99.9%

Farbe und Form: White

Molekulargewicht: 353.97127

Ref: 47-202

Idoxuridine

CAS: 54-42-2

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formel: C₉H₁₁IN₂O₅

Farbe und Form: White Crystalline Powder

Molekulargewicht: 353.97127

Ref: 45-1336001

Idoxuridine

CAS: 54-42-2

Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.

Formel: C₉H₁₁IN₂O₅

Reinheit: 99.45% - 99.62%

Farbe und Form: Crystals From Water Triclinic Solid

Molekulargewicht: 354.1

Ref: TM-T0863

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

Formel: C₉H₁₁IN₂O₅

Reinheit: 98%

Farbe und Form: Solid

Molekulargewicht: 354.0985

Ref: IN-DA003AAB

5-Iodo-2'-deoxyuridine

CAS: 54-42-2

5-Iodo-2'-deoxyuridine

Reinheit: 99%

Molekulargewicht: 354.10g/mol

Ref: 54-OR72935

Idoxuridine

CAS: 54-42-2

Idoxuridine

Reinheit: ≥98%

Molekulargewicht: 354.1g/mol

Ref: 54-BUP18492

5-Iodo-2''-deoxyuridine

CAS: 54-42-2

Formel: C₉H₁₁IN₂O₅

Reinheit: ≥ 98.5%

Farbe und Form: White to off-white crystalline powder

Molekulargewicht: 354.10

Ref: 7W-GP1769

Idoxuridine

Kontrolliertes Produkt

CAS: 54-42-2

Formel: C₉H₁₁IN₂O₅

Farbe und Form: Neat

Molekulargewicht: 354.10

Ref: 86-MM0791.00

Idoxuridine

CAS: 54-42-2

Formel: C₉H₁₁IN₂O₅

Farbe und Form: Neat

Molekulargewicht: 354.10

Ref: 04-C14278800

Idoxuridine RS

CAS: 54-42-2

Farbe und Form: Colorless Or White

Ref: 2K-1015000021

Idoxuridine

Kontrolliertes Produkt

CAS: 54-42-2

Applications Idoxuridine is an antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents.
References Chang, C., et al.: J. Biol. Chem., 267, 22414 (1992), Pressacco, J., et al.: Cancer Res., 54, 3772 (1994),

Formel: C₉H₁₁IN₂O₅

Farbe und Form: Neat

Molekulargewicht: 354.10

Ref: TR-I205750

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a novel nucleoside that has antiviral and anticancer properties. It is an analog of uridine, which is the building block for RNA. 2'-Deoxy-5-iodouridine can be phosphorylated to form diphosphate, monophosphate, and triphosphate forms. It can also be modified to form phosphoramidites or deoxyribonucleosides. This drug has been shown to have anticancer effects on various types of cancer cells and has been used in the treatment of leukemia and other cancers.

Formel: C₉H₁₁IN₂O₅

Reinheit: Min. 99.0 Area-%

Molekulargewicht: 354.1 g/mol

Ref: 3D-Q-201230

2'-Deoxy-5-iodouridine

CAS: 54-42-2

2'-Deoxy-5-iodouridine (IDU) is a nucleoside that inhibits viral replication by inhibiting the synthesis of viral DNA. IDU has been shown to be a potent inhibitor of murine sarcoma virus and human immunodeficiency virus (HIV). IDU also has inhibitory properties on axonal growth, which may be due to its ability to inhibit DNA polymerase II. 2'-Deoxy-5-iodouridine is biocompatible, non-toxic, and can be used in high concentrations without any acute toxicities.

Formel: C₉H₁₁IN₂O₅

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 354.1 g/mol

Ref: 3D-ND05147

2'-Deoxy-5-iodouridine - EP

CAS: 54-42-2

2'-Deoxy-5-iodouridine is a nucleoside analog that inhibits the replication of viruses and other DNA-containing organisms. 2'-Deoxy-5-iodouridine also has inhibitory properties on cell nuclei, which may be due to its ability to bind with DNA and prevent the synthesis of RNA or protein. 2'-Deoxy-5-iodouridine has been shown to inhibit the growth of human HL60 cells in vitro at an optimum concentration of 20 μM. It also inhibits the replication of murine sarcoma virus at an optimum concentration of 16 μM.
2'-Deoxy-5-iodouridine has significant cytotoxicity against solid tumours in mice, which may be due to its ability to inhibit hydrogen fluoride (HF) induced lipid peroxidation and reduce glutathione levels.

Formel: C₉H₁₁IN₂O₅

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 354.1 g/mol

Ref: 3D-ND172114

5-Iodo-2′-deoxyuridine

CAS: 54-42-2

Formel: C₉H₁₁IN₂O₅

Reinheit: 95%

Farbe und Form: Solid, White powder

Molekulargewicht: 354.1

Ref: 10-F092965

5-Iodo-2-Deoxyuridine extrapure, 98%

CAS: 54-42-2

Formel: C₉H₁₁IN₂O₅

Reinheit: min. 98%

Farbe und Form: White to off-white, Crystalline powder

Molekulargewicht: 354.10

Ref: SR-83441

Idoxuridine

CAS: 54-42-2

Farbe und Form: Neat

Ref: 61-FOR0791.00