CAS 61177-45-5

Kaliumclavulanat

Beschreibung:

Kaliumclavulanat ist eine beta-lactamische Verbindung, die als potenter Inhibitor von beta-lactamase-Enzymen dient, die von bestimmten Bakterien produziert werden, um Resistenzen gegen beta-lactam-Antibiotika zu verleihen. Es wird häufig in Kombination mit Penicillin-Antibiotika, wie Amoxicillin, verwendet, um deren Wirksamkeit gegen resistente Bakterienstämme zu erhöhen. Die Substanz erscheint als weißes bis off-white kristallines Pulver und ist in Wasser löslich, was ihre Verwendung in pharmazeutischen Formulierungen erleichtert. Ihr Wirkmechanismus beinhaltet die irreversible Bindung an die aktive Stelle der beta-lactamasen, wodurch die Hydrolyse von beta-lactam-Antibiotika verhindert wird und sie ihre antibakteriellen Wirkungen entfalten können. Kaliumclavulanat wird im Allgemeinen gut vertragen, kann jedoch bei einigen Personen Nebenwirkungen verursachen, einschließlich gastrointestinaler Störungen. Es ist wichtig zu beachten, dass es zwar die Wirksamkeit von Antibiotika erhöht, jedoch selbst keine signifikante antibakterielle Aktivität besitzt. Als pharmazeutisches Mittel ist es entscheidend, Kaliumclavulanat unter medizinischer Aufsicht zu verwenden, um eine angemessene Dosierung sicherzustellen und potenzielle Nebenwirkungen zu mindern.

Formel: C₈H₉NO₅·K

InChl: InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/b4-1-;/t6-,7-;/m1./s1

InChI Key: InChIKey=FERIANDDKNFRJI-JSYANWSFSA-N

SMILES: C(O)(=O)[C@@H]\1N2[C@](O/C1=C\CO)(CC2=O)[H].[K]

Synonyme:

• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, [2R-(2α,3Z,5α)]-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, potassium salt (1:1), (2R,3Z,5R)-
• Brl 14151K
• Clavitesse
• Clavulanic acid potassium salt
• Potassium clavulanate
• Serdaxin
• potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

CAS: 61177-45-5

Formel: C₈H₈KNO₅

Reinheit: 95%

Farbe und Form: Solid

Molekulargewicht: 237.2511

Ref: IN-DA0035ID

Potassium clavulanate with microcrystalline cellulose

CAS: 61177-45-5

Formel: C₈H₈NO₅K

Reinheit: Clavulanic acid: 38.3 - 45.0 %

Farbe und Form: White or almost white powder

Molekulargewicht: 237.25

Ref: 7W-GA1260

Potassium Clavulanate

CAS: 61177-45-5

Formel: C₈H₈NO₅·K

Farbe und Form: White To Off-White Solid

Molekulargewicht: 198.16 39.10

Ref: 4Z-C-328

Clavulanate:Cellulose

CAS: 61177-45-5

Clavulanate:Cellulose

Formel: C₈H₈NO₅·K

Farbe und Form: white or almost white crystalline powder

Molekulargewicht: 237.25g/mol

Ref: 54-BIC581

Clavulanic acid potassium

CAS: 61177-45-5

Formel: C₈H₈NO₅·K

Farbe und Form: Neat

Molekulargewicht: 237.25

Ref: 04-C11668545

Clavulanic Acid Potassium Salt in Cellulose (1:1 mixture)

CAS: 61177-45-5

Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Formel: C₈H₈NO₅·K

Farbe und Form: Mixture

Molekulargewicht: 237.25

Ref: TR-C563751

Clavulanic Acid Potassium Salt

CAS: 61177-45-5

Stability Hygroscopic, Temperature sensitive
Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Formel: C₈H₈NO₅·K

Farbe und Form: Light Yellow To Dark Brown

Molekulargewicht: 237.25

Ref: TR-C563750

Potassium clavulanate - 1:1 mixture with silicon dioxide

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Formel: C₈H₈NO₅·K

Reinheit: Min. 95%

Farbe und Form: White Powder

Molekulargewicht: 237.25 g/mol

Ref: 3D-FP30769

Clavulanate potassium

CAS: 61177-45-5

Clavulanate potassium,β-Lactamase inhibitor with antibiotic activity.

Formel: C₈H₈KNO₅

Farbe und Form: Solid

Molekulargewicht: 237.25

Ref: TM-T67431

Potassium clavulanate (40%) : silicon dioxide mixture

CAS: 61177-45-5

Formel: C₈H₈KNO₅

Reinheit: 95.0%

Farbe und Form: Solid

Molekulargewicht: 237.252

Ref: 10-F237796

Potassium clavulanate - 1:1 mixture with cellulose, Antibiotic for Culture Media Use Only

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls.

Formel: C₈H₈KNO₅

Reinheit: Min. 95.0 Area-%

Molekulargewicht: 237.25 g/mol

Ref: 3D-W-105420

Potassium clavulanate

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls. Potassium clavulanate is also used as an antimicrobial agent for blood culture technique and antimicrobial treatment.

Formel: C₈H₈NO₅·K

Reinheit: Min. 95%

Farbe und Form: White Powder

Molekulargewicht: 237.25 g/mol

Ref: 3D-FP10878

Potassium clavulanate - 1:1 mixture with cellulose

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Formel: C₈H₈NO₅·K

Reinheit: Min. 95%

Farbe und Form: Powder

Molekulargewicht: 237.25 g/mol

Ref: 3D-FP16197