CAS: 639089-54-6 - Tozasertib

Formel: C₂₃H₂₈N₈OS

InChl: InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)

InChI Key: InChIKey=GCIKSSRWRFVXBI-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(SC=2N=C(C=C(N2)N3CCN(C)CC3)NC4=NNC(=C4)C)C=C1)C5CC5

Synonyme:

• Cyclopropanecarboxylic acid N-[4-[[4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide
• Mk 0457
• N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]cyclopropanecarboxamide
• N-[4-({4-(4-Methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide
• N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide
• N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide
• Tozasertib
• cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]-2-pyrimidinyl]thio]phenyl]-
• cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-
• VX 680

N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide

CAS: 639089-54-6

• Formel: C₂₃H₂₈N₈OS
• Reinheit: %
• Farbe und Form: Solid
• Molekulargewicht: 464.5864

Tozasertib

CAS: 639089-54-6

Tozasertib

CAS: 639089-54-6

• Formel: C₂₃H₂₈N₈OS
• Farbe und Form: Pale Brown Solid
• Molekulargewicht: 464.59

Tozasertib

CAS: 639089-54-6

Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).

• Formel: C₂₃H₂₈N₈OS
• Reinheit: 99.99%
• Farbe und Form: Solid
• Molekulargewicht: 464.59

Tozasertib

CAS: 639089-54-6

Applications A multikinase inhibitor once used for cancer treatment. References Ulisse, S., et al.: J. …

• Formel: C₂₃H₂₈N₈OS
• Farbe und Form: Neat
• Molekulargewicht: 464.59

VX 680

CAS: 639089-54-6

Aurora kinase inhibitor; antineoplastic

• Formel: C₂₃H₂₈N₈OS
• Reinheit: Min. 95%
• Farbe und Form: White Powder
• Molekulargewicht: 464.59 g/mol